摘要
Abstract
AIM To establish a gas chromatography method for determining the content of acetaminophen and sodium benzoate content in acetaminophen oral liquid preparation. METHODS Shimadzu GC - 17AA gas chromatograph used SE -54 fused silica capillary column (30 m×0.25 mm×0.5 μm). The detector was hydrogen flame detector (FID),carrier gas was high purity N2.The FID temperature was 300℃, injection volume was 1 μL, gas split ratio was
20:1, the initial column temperature was 50℃, reached to 120 ℃ with the speed of 25℃·min-1 and keeping for 3 min, reached to 170℃ with the speed of 8℃ · min-1 and keeping for 10 min,reached to 250℃ with the speed of 10℃ ·min-1 and keeping for 5 min. RESULTS The linear range of acetaminophen and sodium benzoate was 39.87 - 398.7 mg·L-1 (r = 0.9993) and2.006-6.018 mg·L-1(r = 0.9991), respectively. The regression equation was A = 3552039ρ + 57 673,A=450 650p +41 921. The average recovery (n=9) was 97.28% (RSD = 0.87%) and 95.15% (RSD = 1.32%),respectively. CONCLUSION The method is simple, rapid, specific, and can be used to effectively control the content of acetaminophen and sodium benzoate in acetaminophen oral liquid preparation.关键词
气相色谱法/对乙酰氨基酚口服液体制剂/对乙酰氨基酚/苯甲酸钠Key words
gas chromatography/ acetaminophen oral liquid preparation/ acetaminophen/ sodium benzoate
