中国免疫学杂志2012，Vol.28Issue(7)：648-651,656,5.DOI:10.3969/j.issn.1000-484X.2012.07.017
自体DC-CIK细胞联合培美曲塞治疗老年非小细胞肺癌的疗效与安全性
Efficacy and safety of autologous DC and CIK cells comined Pemetrexed in the treatment of elderly patients with non-small cell lung cancer
摘要
Abstract
Objective: Observation of clinical efficacy and toxicity about advanced non-small cell lung cancer in the elderly patients with the treatment of autologous cytokine-induced dendritic cells (DC) and killer cells (CIK) combined Pemetrexed. Methods; Elderly (65-79) patients with IHA-IV period non-small cell lung cancer 47 cases confirmed by pathology or cytology were enrolled into two groups; 24 cases received the treatment of transfusing for autologous CIK and DC combined 500 mg/m2 Pemetrexed intravenously once a day,which came from the peripheral blood of themselves and amplified, during CIK/DC-CIK phenotype detection by flow cytom-etry, and another 23 patients received the treatment of 500 mg/m Pemetrexed intravenously once a day. 21 days is a period. 47 patients were given more than 2 periods of chemotherapy and evaluated of efficacy and toxicity every 2 periods. Results;The effective rate (with a disease control rate) of combination therapy group(24 cases) and chemotherapy group(23 cases) was 66. 67% and 56. 52% (P＜0.05) , median survival was 9.3 and 8. 7 months ( P ＞ 0. 05) , the 1-year survival rate was 27. 6% and 25.4% (P ＞ 0. 05) . The main toxicity of two therapys was bone marrow suppression, gastrointestinal reaction and weak. Granulocytopenia was significantly less occurred in combination therapy group than in chemotherapy group (Ⅰ-Ⅱ ; 9. 05% vs 19. 09% ,P ＜0. 05; Ⅲ-Ⅳ; 2. 52% vs 9. 27% , P ＜0. 05) . Gastrointestinal reaction was significantly less occurred in combination therapy group than in chemotherapy group (Ⅰ-Ⅱ ; 6.29%vs 15.09% ,P＜0. 05; I-IV: 2.76% vs 8.91% , P ＜ 0. 05). Conclusion: The therapeutic effects of elderly non-small cell lung cancer patients accepted either combination therapy or chemotherapy are good, but the combination therapy group shows the better efficiency, the fewer toxicity and a higher quality of life than chemotherapy group.关键词
非小细胞肺癌/培美曲塞二钠/CIK细胞/DC细胞/过继免疫疗法Key words
Non-small cell lung/ Pemetrexed/ CIK cells/DC cells/Adoptive immunotherapy分类
医药卫生引用本文复制引用
彭大为,李建旺,元建华,刘英平,于伟玲,孟娟,罗洁..自体DC-CIK细胞联合培美曲塞治疗老年非小细胞肺癌的疗效与安全性[J].中国免疫学杂志,2012,28(7):648-651,656,5.基金项目
本文为海南省卫生厅资助项目(琼卫2010-70) （琼卫2010-70）
