首页|期刊导航|中国神经再生研究（英文版）|Nav1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain
中国神经再生研究（英文版）2012，Vol.7Issue(20)：1540-1544,5.DOI:10.3969/j.issn.1673-5374.2012.20.003
Nav1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain
Nav1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain
摘要
Abstract
Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3-28 days following model induction. The results of immunohistochemistry,western blot assays and reverse transcription-PCR showed that Nav1.7 protein and mRNA expression was significantly increased in the injured dorsal root ganglia. These findings indicated that Nav1.7 might play an important role in the model of chronic neuropathic pain.关键词
Nav1.7/ neuropathic pain/ dorsal root ganglia/ sodium channel/ sensitization/ hyperalgesia/ regeneration/neural regenerationKey words
Nav1.7/ neuropathic pain/ dorsal root ganglia/ sodium channel/ sensitization/ hyperalgesia/ regeneration/neural regeneration引用本文复制引用
Chao Liu,Jing Cao,Xiuhua Ren,Weidong Zang..Nav1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain[J].中国神经再生研究（英文版）,2012,7(20):1540-1544,5.基金项目
This study was supported by the National Natural Science Foundation of China (The mechanism of Nav1.7 (encoded by SCN9A gene) activated by chronic neuropathic pain,and the experimental study of analgesia by SCN9A RNAi),No.81171059. （The mechanism of Nav1.7 (encoded by SCN9A gene）
