首页|期刊导航|中国神经再生研究（英文版）|Buyang Huanwu decoction enhances cell membrane fluidity in rats with cerebral ischemia/reperfusion
中国神经再生研究（英文版）2012，Vol.7Issue(21)：1605-1610,6.DOI:10.3969/j.issn.1673-5374.2012.21.001
Buyang Huanwu decoction enhances cell membrane fluidity in rats with cerebral ischemia/reperfusion
Buyang Huanwu decoction enhances cell membrane fluidity in rats with cerebral ischemia/reperfusion
摘要
Abstract
After bilateral carotid artery occlusion for 30 minutes and reperfusion for 2 hours, distinct patho-logical changes presented in the cerebral cortex and cerebellum of rats. Compared with normal rats, nerve cell membrane fluidity significantly decreased in ischemia/reperfusion rats as detected by spin-labeling electron spin resonance, consistent with order parameter S and rotational correlation time TC measurements. Brain nerve cells from rats with ischemia/reperfusion injury were cultured with 1-100 mg/mL Buyang Huanwu decoction. Results showed that Buyang Huanwu decoction gradually increased membrane fluidity dose-dependently to normal levels, and eliminated hydroxide (OH·) and superoxide (O2·) free radicals dose-dependently. These findings suggest that Buyang Huanwu decoction can protect against cell membrane fluidity changes in rats with ischemia/ reper-fusion injury by scavenging free radicals.关键词
Buyang Huanwu decoction/ ischemia/reperfusion/ electron spin resonance/ cell membrane fluidity/ free radical/ brain/ neural regenerationKey words
Buyang Huanwu decoction/ ischemia/reperfusion/ electron spin resonance/ cell membrane fluidity/ free radical/ brain/ neural regeneration引用本文复制引用
Chenxu Li..Buyang Huanwu decoction enhances cell membrane fluidity in rats with cerebral ischemia/reperfusion[J].中国神经再生研究（英文版）,2012,7(21):1605-1610,6.基金项目
This study was supported by the Doctor Foundation (2008) in Shanxi Datong University. （2008）
