中国输血杂志2012，Vol.25Issue(4)：300-303,4.
2458名中国汉族人类HPA-1～6、15基因多态性的研究
The polymorphism of HPA-1 ～6、15 in Chinese Han population
摘要
Abstract
Objective To analyze human platelet antigens (HPA)1-6,15 polymorphism,and study the allele frequencies in the North Chinese Han and South Chinese Han. Methods The genotypes of HPA1 -6,15 systems were performed by FLOW-SSO for 2 458 samples. Results The gene frequencies were 0.991 7,0.008 3,0.955 2,0.044 8,0.558 6,0.441 4,0.998 0,0.0020,0.986 2,0.013 8,0.985 6,0.0144,0.545 2,0.454 8 for HPA-la,HPA-lb,HPA-2a,HPA-2b,HPA-3a,HPA-3b,HPA-4a,HFA-4b,HPA-5a,HPA-5b,HPA-6a,HPA-6b,HPA-15a,HPA-15b,respectively.The phenotype frequencies of HPAl-6,15 in the South Chinese Han was compared to the frequencies in the north Chinese Han. There is significant deviation from Hardy-Weinbery equilibrium within HPA-l ,3 in the south Chinese Han and north Chinese Han(χ2 = 15. 032 0、5.418 8 ,P <0.05). There was a good fit to Hardy-Weinbery equilibrium within each group. Conclusion The highest heterozygotes are HPA-3 and HPA-15,which indicate that the original difference of HPA-l and HPA-3 in South and North of China. In order to provide HPA-matched platelet transfusion in alloimmune thromboeytopenic patients,the building of China HPA-typed plateletpheresis donor registry is very useful关键词
中国汉族人群/人类血小板抗原/FLOW-SSO/基因频率Key words
Chinses Han population/ HPA /Flow-sequence specific oligonucleotide probes (FLOW-SSO)/Gene frequency分类
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周丹,张印则,庄乃保,孔令魁..2458名中国汉族人类HPA-1～6、15基因多态性的研究[J].中国输血杂志,2012,25(4):300-303,4.基金项目
深圳市科技局科研基金项目(201003200) （201003200）
