中国实用儿科杂志2012，Vol.27Issue(4)：303-305,3.
哮喘预测指数评估婴幼儿喘息转归临床观察
The effect of asthma predictive index in assessing prognosis of infant with recurrent wheeze
摘要
Abstract
Objective To study the effect of asthma predictive index in assessing prognosis of infant with recurrent wheeze. Method Totally 129 recurrent wheeze children were enrolled in the study in random, of whom43 infants were assigned asthma predictive index positive (A group), 86 to asthma predictive index negative (B group), and 69 to control group (C group).They were tested tidal breathing pulmonary function in remission. Compare minute ventilation (MV),tidal volume/kg( VT/ kg),respiratory rate(RR),inspiratory time(Ti),expiration time(Te),ratio Ti to Te(Ti/ Te), ratio of time taken to reach peak tidal expiratory flow to total expiratory time(TPEF/TE) .ratio of volume taken to reach peak tidal expiratory flow to total expiratory volume(VPEF/VE), peak expiratory flow(PTEF)and ratio of tidal expiratory flow respectively at 25%, 50% and 75% remaining expiration to peak expiratory flow(TEF25% ,TEF50%, TEF75%) between groups. Totally 67 children completed the 4 years of follow-up. Among these children, A group had 26, B group had 23 and C group had 18. They all used impulse oscillometry to test. Compare impedance at 5Hz(Z5) .reactance at 5Hz(X5) .resonant frequency(Fres) .resistance at 5Hz(R5) and resistance at 20Hz(R20)between groups. Result In comparison with B group and C group, TPEF / TE, VPEF /VE, Ti/Te, TEF25%, TEF50% and TEF75% were significantly lower, TE was higher in A group, which had significant statistical difference (P<0.01) ; compare B group with C group, B group had much lower TPEF / TE and VPEF /VE, which had significant difference (P< 0.05). In the follow-up children, in comparison with B group and C group, X5 was lower, Fres was higher in Agroup, which had statistical significant difference (P< 0.01). Compared to B group, A group had much higher Z5, which had statistical difference(P<0.05). Conclusion Recurrent wheeze infant can result in lung function impairment at an early age. In asthma predictive index positive children, lung function impairment will continue to preschool age, which may develop into asthma later and need an early intervention.关键词
潮气肺功能/脉冲震荡肺功能/哮喘预测指数/哮喘Key words
tidal breathing pulmonary function/ impulse oscillometry/ asthma predictive index/ asthma分类
医药卫生引用本文复制引用
曹顺顺,蔡晓红,李秀翠,胡青青,梁冬施,温正旺,何陈谦..哮喘预测指数评估婴幼儿喘息转归临床观察[J].中国实用儿科杂志,2012,27(4):303-305,3.基金项目
浙江省医学会临床科研基金项目(2008ZYC26) （2008ZYC26）
义乌市科技计划项目(08-3-05) （08-3-05）
