中国兽医科学2012，Vol.42Issue(6)：637-641,5.
头孢噻呋钠-壳聚糖纳米粒的制备及相关性质的研究
Preparation and characterization of ceftiofur sodium-chitosan nanoparticles
摘要
Abstract
To prolong the action time of ceftiofur sodium, ceftiofur sodium-chitosan nanoparticle（CNP） were prepared by ionic crosslinking method. Morphology, particle size and distribution, encapsulation efficiency and drug loading rate were investigated. In result, the appearance of prepared CNP was regular with the diameter being of 179.4±39.5 nm. The encapsulation efficiency and drug-loading rate were 84.31% ±2.53 % and 6.69 %±0.18 % respectively. The in vitro release experiment showed that the ceftiofur sodium was released above 90% at 4 h post-treatment,meanwhile only 60% was released from CNP. In conclusion, the CNP preparation procedure is feasible and CNP have obvious sustained-release effect.关键词
头孢噻呋钠/壳聚糖/纳米粒/质量评价Key words
ceftiofur sodium/chitosan/nanoparticle/quality evaluation分类
农业科技引用本文复制引用
符华林,黄平全,付强,杨元国,张伟,唐文..头孢噻呋钠-壳聚糖纳米粒的制备及相关性质的研究[J].中国兽医科学,2012,42(6):637-641,5.基金项目
教育部“长江学者和创新团队发展计划”创新团队项目 （）
