中国实用内科杂志2012，Vol.32Issue(6)：461-463,473,4.
尿微量白蛋白排泄率与血清促甲状腺激素相关性研究
The correlation of thyrotropin and urine albumin creatine ratio
刘爱华 1李宁娜 1于嘉澍 1鲁丽 1白雪 1王森 1单忠艳 1滕卫平 1赖亚新 1姜凤伟 1王蓓蓓 1王佳妮 1陈彦彦 1李祉丹 1单玲 1史良凤1
作者信息
- 1. 中国医科大学附属第一医院内分泌科辽宁省内分泌疾病重点实验室,沈阳110001
- 折叠
摘要
Abstract
Objective To explore the relationship between urine albumin creatine ratio (ACR) and serum thyrotropin (TSH). Methods In October 2007 ,a total of 1534 adult inhabitants in Dadong district of Shenyang were asked to fulfill the questionnaires and measure the blood pressure, height .weight and waist. The vein blood was drawn to measure thyrotropin ( TSH ) .thyroid peroxidase antibody (TPOAb) .Thyroglobulin antibody (TGAb) .fasting plasma glucose( FPG) ,0G-TT 30minPG,OGTT 2hPG,fasting insulin,triglyceride ( TG ) .total vholestoral ( TC ) .high density lipoprotein cholesterol ( HDL-C) and low density lipoprotein cholesterol ( LDL-C). Fasting urine samples were collected for measurement of cre-atinine and microalbumin.and the microalbumin/creatinine ratio (ACR) was calculated. Results The prevalence of mi-croalbuminuria was 11.8% and was increasing with age ( P < 0.01). Compared with subjects with normal microalbumin, the waist,BMI,systolic pressure,diastolic pressure,heart rate,FPG,OGTT 30minPG,OGTT 2hPG,serum TG.and homeo-stasis model assessment insulin resistance ( HOMA-IR) were all significantly increased in subjects with microalbuminuria (P < 0.05). However serum TSH, the prevalence of subclinical hypothyroidism and hyperthyroidism was no statistical difference between the two groups (P > 0.05). Hyperglycemia and hypertension was independently associated with the prevalence of microalbuminuria (hypertension OR = 1. 868, P < 0. 01; hyperglycemia OR = 1.469, P < 0.05 ). Conclusion ACR was not related with serum TSH,while the hyperglycemia and hypertension was independently associated with the prevalence of microalbuminuria.关键词
尿微量白蛋白排泄率/微量白蛋白尿/促甲状腺激素/代谢综合征Key words
microalbumin creatinine ratio/microalbuminuria,thyrotropin/metabolic syndrome分类
医药卫生引用本文复制引用
刘爱华,李宁娜,于嘉澍,鲁丽,白雪,王森,单忠艳,滕卫平,赖亚新,姜凤伟,王蓓蓓,王佳妮,陈彦彦,李祉丹,单玲,史良凤..尿微量白蛋白排泄率与血清促甲状腺激素相关性研究[J].中国实用内科杂志,2012,32(6):461-463,473,4.
