摘要
Abstract
Objective To investigate the effect of Ulinastatin eardioplegia solution against myocardial injury during extracorpo-real circulation. Methods 40 patients suffered congenital heart disease ( ASD or VSD ) were randomly divided into Ulinastatin ( U ) group and contra! ( C ) group. U group patients were treated with StThomas cardioplegia solution mixed with Ulinastatin ( 5000 U/kg) while C group patients were only given St Thomas cardioplegia solution. CKMB, cTnl, TNF — a, IL — 6, MDA and SOD were detected before induction and after aorta opening and they were also detected 0, 6 h, 24 h and 48 h after surgery. Heart recovery time, use of vasoactive agent and length of stay were recorded. Results There were no difference in extracorporeal circulation time and aorta interrupted time between the two groups, so was their length of stay. Automatic heart recover rate was higher in U group. Plasma concentration of CKMB, cTnl, TNF —α, IL — 6 and MDA were increased after aorta opening while SOD was obviously decreased, and all of these indexes reached their peak concentration at the end of surgery. Maximal dose of dopamine using of U group was significantly lower than C group while with no difference in noradrenaline. Data correlation analysis showed that there were positive relationship between TNF-α, IL-6 and CKMB, IL-6 and cTnl, MDA and CKMB. Negative relationship was detected between SOD, CKMB and cTnl. Conclusion Ulinastatin decreased cardiac myocyte injury and cardiac dysfunction by alleviating systemic inflammatory reaction and oxygen radicals injury.关键词
乌司他丁/心肌保护/停搏液/炎性因子/氧自由基Key words
Ulinastatin/ Myocardial Preservation/ Cardioplegic Solution/ Inflammatory Factor/ Oxygen Radicals分类
医药卫生
