中国体外循环杂志2012，Vol.10Issue(2)：87-91,5.
抗炎因子及全身炎症反应评分在心脏手术围术期变化规律及蛋白酶抑制剂的影响
Interleukin-10, monocyte and SIRS score in cardiac surgery with cardiopulmonary bypass and the impact of protease inhibitor
石佳 1李立环 1肖文静 1王古岩 1薛庆华 1吕红 1何爱霞 1袁素 1李军 1张喆1
作者信息
- 1. 100037,北京,中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院
- 折叠
摘要
Abstract
Objective To evaluate interleukin — 10, monocyte and systemic inflammatory response syndrome ( SIRS) score in cardiac surgery with cardiopulmonary bypass ( CPB ) and the impact of protease inhibitor. Methods A total of 300 consecutive patients receiving cardiac surgery with CPB were randomly assigned to two groups; ulinastatin group ( n = 150 ) and control group ( n = 150 ). The patient in trial group was administered ulinastatin 1,000,000 units after induction, after heparization and after neutralization. At the time point of before incision ( Tl ), at the end of the operation ( T2 ), 8 hours ( T3 ), 16 hours ( T4 ), 24 hours ( T5 ), 48 hours ( T6 ) and 72 hours ( T7 ) postoperativcly, plasma IL — 10 concentration, SIRS score, the count of leucocyte and the percentage of monocyte was evaluated. Results The IL - 10 concentration decreased significantly at T2 ( P ＜0. 01 ) and reached the bottom at T2 and T5 in the ulinastatin group and the control group respectively. The concentration was significantly lower in the control group than the ulinastatin group ( P ＜0.01 ) at T3 — T7. The average SIRS score increased at T2 and reached its peak at T3. The average SIRS score was significantly higher in the control group than the ulinastatin group ( P ＜ 0.01 ) at T3 — T6. Leucocyte increased significantly at T2 ( P ＜ 0.01 ) and reached the peak at T3. The count of leucocyte was significantly lower in the ulinastatin group than the control group at T3 — T6 ( P ＜0. 01 ). The percentage of monocyte decreased significantly at T2 ( P ＜0.01 ). The percentage was significantly higher in the ulinastatin group than the control group at T3 ( P ＜0. 01 ). Conclusion Protease inhibitor can significantly protect interleukin — 10 and monocyte, reduce SIRS score and the count of leucocyte in patients receiving cardiac surgery with cardiopulmonary bypass.关键词
体外循环/白细胞介素-10/全身炎症反应综合征/蛋白酶抑制剂Key words
Cardiopulmonary Bypass/ Interleukin — 10/ Systemic Inflammatory Response Syndrome/ Protease Inhibitor分类
医药卫生引用本文复制引用
石佳,李立环,肖文静,王古岩,薛庆华,吕红,何爱霞,袁素,李军,张喆..抗炎因子及全身炎症反应评分在心脏手术围术期变化规律及蛋白酶抑制剂的影响[J].中国体外循环杂志,2012,10(2):87-91,5.
