中国体外循环杂志2012，Vol.10Issue(2)：95-98,108,5.
体外循环对先天性心脏病婴幼儿循环内皮祖细胞影响
Effect of extracorporeal circulation on circulating endothelial progenitor cells in infants with congenital heart disease
任建立 1姚建民 1刘晋萍 2程伟伟 1赵向东 1陆龙 1刘静 1武书玲 1郑睿1
作者信息
- 1. 100700,北京,北京军区总医院心肺血管病一区
- 2. 100037,北京,中国医学科学院,北京协和医学院,阜外心血管病医院体外循环科
- 折叠
摘要
Abstract
Objective This study was Incus to observe the influence of extrarorporeal circulation ( ECC ) on circulating endothelial progenitor cells ( EPCs ) in infants with congenital heart disease by measuring the EPCs amount. Methods Between July 2010 and December 2010, 40 infants with congenital heart disease and pulmonary arterial hypertension were divided into ECC group and off — pump group. In off — pump group, 20 cases received ligation of patent ductus arteriosus and closure of art rial sepectal defect without cardio pul mo nary bypass. In ECC group, 20 cases had open heart operations with cardio pulmonary bypass. The amount of circulating EPCs counted by flow cytometer at anesthesia completion ( T1 ), the end of surgery ( T2 ), 4 h ( T3 ), 24 h ( T4 ) and 72 h ( T5 ) after operations. The relation of ECC and EPCs amount was analyzed. Results The amount of circulating EPCs in the two groups had no statistically significant differences at T1( P ＞0. 05 ). The amount of circulating EPCs in ECC group was significantly higher than that in off —pump group at T3 ( P ＜0. 01 ). The amount of circulating EPCs at T2, T4, T5 in ECC group was significantly lower than that at Tl and those time points in off - pump group ( P ＜0.01 ). Conclusion The levels of circulating EPCs reduce after ECC.关键词
体外循环/内皮祖细胞/先天性心脏病/婴幼儿Key words
Extrarorporeal circulation/ Endothelial progenitor cells/ Congenital heart disease/ Infants分类
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任建立,姚建民,刘晋萍,程伟伟,赵向东,陆龙,刘静,武书玲,郑睿..体外循环对先天性心脏病婴幼儿循环内皮祖细胞影响[J].中国体外循环杂志,2012,10(2):95-98,108,5.
