中国心理卫生杂志2012，Vol.26Issue(6)：429-434,6.DOI:10.3969/j.issn.1000-6729.2012.06.007
BAIAP2基因多态与儿童注意缺陷多动障碍共患学习困难的关联分析
Association study of BAIAP2 gene polymorphisms and attention-deficit/hyperactivity disorder comorbid learning disability
摘要
Abstract
Objective:To investigate the association between brain-specific angiogenesis inhibitor 1-associated protein 2(BAIAP2) gene polymorphisms and attention deficit hyperactivity disorder (ADHD) comorbid with learning disability (LD). Methods: Totally 731 ADHD children comorbid with LD (625 boys and 106 girls) and 957 controls (617 males and 340 females) were selected. The diagnosis was based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). The clinical information and blood samples of the subjects were collected. Nine single nucleotide polymorphisms (SNPs) of BAIAP2 were genotyped implementing Taq-ManTM real-time PCR genotyping technique. The design of case-control study was carried out Results: The rs8079626/G (case-control frequencies 0. 638 vs. 0.604, P<0.05) and rs4969385/T (0.179 vs. 0.150, P<0.05)were found to be associated with ADHD children comorbid with LD. The rs3934492/C (0.572 vs. 0.532, P < 0.05) and rs4969385/T (0.180 vs. 0. 142,P<0.01) had significant association with ADHD boys comorbid with LD. The rs4969239/G (0.426 vs. 0. 329, P< 0.05) and rs4969358/A (0.472 vs. 0. 389, P<0. 05) had significant association with ADHD girls comorbid with LD. The haplotype AAGG which was consisted by rs4969239-rs4969358-rs6565531-rs8079626 was associated wilh ADHD children comorbid with LD (0.100 vs. 0.065, P < 0.01) and ADHD boys comorbid with LD (0.101 vs. 0.065, P <0.01 j. Conclusion: It suggests that BAIAP2 gene may be involved in the etiology of ADHD children comorbid with LD, and the mechanisms may be sexual dimorphism.关键词
注意缺陷多动障碍/学习困难/BAIP2基因/关联研究Key words
attention deficit hyperactivity disorder/ learning disability/ BAIAP2 gene/ association study分类
医药卫生引用本文复制引用
李泽华,钱秋谨,刘璐,李海梅,杨莉,王玉凤..BAIAP2基因多态与儿童注意缺陷多动障碍共患学习困难的关联分析[J].中国心理卫生杂志,2012,26(6):429-434,6.基金项目
国家自然科学基金(81071109) （81071109）
“十一五”国家科技支撑计划资助(2007BA117803) （2007BA117803）
