中国循证儿科杂志2012，Vol.7Issue(4)：274-277,4.DOI:10.3969/j.issn.1673-5501.2012.04.007
GDF5基因rs224331多态性与汉族青少年体格发育指标关联分析
The association of GDF5 gene rs224331 polymorphism with physical development parameters of Chinese Han adolescents
摘要
Abstract
Objective To explore the association of growth differentiation factor 5 ( GDF5 ) gene rs224331 polymorphism with height, weight and BMI in Chinese Han adolescents. Methods A total of 1 790 adolescents and young adults aged from 17 to 22 years were recruited from a technical school in Jiangsu province of China. Data of height and weight were collected from participants at the time of blood collection. BMI was calculated according to its formula. GDF5 gene rs224331 polymorphism was genotyped by Taqman probe and real-time PCR methods. Results 97. 9%( 859 males, 895 females, totally 1 754 ) of the 1 790 subjects were successfully genotyped. At rs224331 locus, AA was dominant genotype( 51.7% ), followed by AC ( 39. 6% )and CC genotypes( 8.7% ). There was no statistically significant association of rs224331 polymorphism with height in neither males nor females ( P =0.728 and 0.723 respectively). The genotype of rs224331 was significantly associated with weight and BMI in male subjects ( P value was 2. 32 X 10 ~ and 3. 19 X 10 ~ ). However, this association was not observed in females ( Pvalue was 0.713 and 0. 921 ). Conclusions The current population-based study showed that the rs224331 polymorphism was not associated with height in neither males nor females. While GDF5 gene variant was associated with weight and BMI in Chinese Han young adult males.关键词
生长分化因子5/基因多态性/身高/体重/体质指数/汉族Key words
Growth differentiation factor 5/ Gene polymorphism/ Height/ Weight/ BMI/ Han population引用本文复制引用
裴舟,程若倩,奚立,叶蓉,赵诸慧,郑章乾,章淼滢,罗飞宏,李晓静,王健民,杨毅,高玲玲,沈水仙,支涤静,陆炜,陆忠..GDF5基因rs224331多态性与汉族青少年体格发育指标关联分析[J].中国循证儿科杂志,2012,7(4):274-277,4.基金项目
卫生行业科研专项项目(遗传代谢病筛查诊断适宜性技术的推广与应用):201002006 （遗传代谢病筛查诊断适宜性技术的推广与应用）
