中国药房2012，Vol.23Issue(16)：1490-1492,3.DOI:10.6039/j.issn.1001-0408.2012.16.18
尼莫地平对急性脑梗死患者神经功能及基质金属蛋白酶9的影响
Effect of Nimodipine to the Nerve Function and the MMP-9 in the Patients of Acute Cerebral Infarction
杨嘉君 1金春峰2
作者信息
- 1. 上海交通大学附属第六人民医院神经内科,上海 200233
- 2. 上海市奉贤区奉城医院神经科,上海201411
- 折叠
摘要
Abstract
OBJECTIVE: To discuss cerebral protection efficacy of nimodipine for the patients with acute cerebral infarction. METHODS: 60 acute cerebral infarction patients were divided into nimodipine group(30 cases) and control group(30 cases). The BI measuring scales were used for evaluation before treatment and on the 14th and 30th day after treatment. The level of plasma MMP-9 was detected before treatment and on the 3th and 7th day after treatment. RESLUTS: After treatment 14 and 30 days, measuring scale of BI of nimodipine group and control group were (67.98 ± 12.67) point vs. (89.02 ± 10.37) point, (60.06 ± 11.89) point vs. (78.83± 13.02) point. Compared with control group, the change was more significant (P<0.05 or P<0.01). After treatment 3 and 7 days. The level of MMP-9 of nimodipine group and control group were (238.73 ± 123.37) mg·L‐1 vs. (86.23 + 29.45) mg·L‐1,(299.83± 119.47) mg·L‐1 vs.(105.56 + 31.17)mg·L‐1. There was significant difference between 2 groups(P<0.05 or P<0.01). CONCLUSION: Nimodipine could effectively improve the nerve function handicap for the patients with acute cerebral infarction and have good efficacy.关键词
急性脑梗死/尼莫地平/脑保护/基质金属蛋白酶9Key words
Acute cerebral infarction/ Nimodipine/ Neuroprotection/ Matrix metal protease 9
分类
医药卫生引用本文复制引用
杨嘉君,金春峰..尼莫地平对急性脑梗死患者神经功能及基质金属蛋白酶9的影响[J].中国药房,2012,23(16):1490-1492,3.
