摘要
Abstract
OBJECTIVE: To evaluate the clinical efficacy of Compound danshen injection combined with vitamin E in the treatment of neonatal scleredema. METHODS: According to evidence based medicine methods, randomized controlled trials (RCTs) were retrieved databases of CBM, CNKI, VIP, Wanfang, PubMed and the Cochrane Library. RCTs of Compound danshen injection combined with vitamin E in the treatment of neonatal scleredema were included, including studies' quality was evaluated by Jadad method, and Meta-analysis of homogeneity study results was performed. RESULTS: A total of 12 studies involving 969 patients were gathered, all of which Jadad score was 3. Meta-analysis results indicated the difference of excellence rate[RR=1.72, 95%CI(1.38,2.15),P<0.00001], scleredema improving time[MD=-1.81, 95%CI(-1.92, -1.70) , P<0.00001], scleredema regression time[MD= -1.58, 95%CI( -1.82, -1.33), P<0.000 01], body temperature regression time[MD=-2.40, 95%CI (-3.34, -l.46),P<0.000 0l]and bospitalizationtime[MD=-2.95, 95%CI(-3.55, -2.36), P<0.000 01] were significant between trial group and control group. CONCLUSION: Based on evidence recently, Compound danshen injection combined with vitamin E on the basis of conventional therapy is better than conventional therapy alone for neonatal scleredema. But as a result of this research inctuded studies of lower quality, to be further clinical sample RCT to continue to study.关键词
复方丹参注射液/维生素E/新生儿硬肿症/Meta分析/系统评价Key words
Compound danshen injection/ Vitamin E/ Neonatal scleredema/ Meta-analysis/ Systematic review分类
医药卫生
