中国药房2012，Vol.23Issue(17)：1543-1545,3.DOI:10.6039/j.issn.1001-0408.2012.17.03
双歧杆菌对应激模型大鼠肠道通透性的影响
Influence of Bifidobacterium on the Intestinal Permeability in Stress Model Rats
摘要
Abstract
OBJECTIVE: To study the improvement effect of Bifidobacterium on intestinal permeability in stress model rats, and synergistic reaction of Bifidobacterium combined with Montmorillonite powders. METHODS: 50 SD rats were randomly divided into normal control group, model control group, Bifidobacterium treatment group (2×108 cfu). Montmorillonite powders treatment group (0.6 g·kg‐1) and drug combination group (Bifidobacterium 2x10" cni+Montmorillonite powders 0.6 g·kg‐1). Those rats were given medicine once a day via i.g. for consecutive 7 days. Stress model was established by WAS in the latter 4 groups. On 8th day each group was given mannitol 80 mg and sucralose 60 mg, and the amount and ratio of mannitol and sucralose in urine were determined S h and 24 h after administration to evaluate intestinal permeability. Rats were sacrificed at the end of experiment, and the content of corticotrophin releasing factor (CRF) and adrenocorticotrophic hormone (ACTH) in serum were determined. RESULTS: Compared with normal control group, the 24 h mannitol concentration, the serum levels of CRF and ACTH in model control group increased significantly (P<0.05). Compared with model control group, serum levels of ACTH in Bifidobacterium treatment group and drug combination group decreased significantly (P<0.05). Other parameters all decreased but had no statistical significance. CONCLUSION: Bifidobacterium can improve intestinal permeability of stress model rats, protect intestinal mucosa. In the treatment of intestinal dysfunction caused by chronic psychological stress, Bifidobacterium and Montmorillonite powders are not in synergies.关键词
双歧杆菌/应激模型/大鼠/肠道通透性/蒙脱石散Key words
Bifidobacterium/ Stress model/ Rats/ Intestinal permeability/ Montmorillonite powders分类
医药卫生引用本文复制引用
冀建伟,付蕾,郑鹏远,张军..双歧杆菌对应激模型大鼠肠道通透性的影响[J].中国药房,2012,23(17):1543-1545,3.基金项目
国家自然科学基金资助项目(30772028) （30772028）
