中国药房2012，Vol.23Issue(17)：1556-1558,3.DOI:10.6039/j.issn.1001-0408.2012.17.07
利福喷丁的溶解性与稳定性考察
Study on Solubility and Stability of Rifapentine
摘要
Abstract
OBJECTIVE: To study the solubility and stability of rifapentine, and to lay a good foundation for the further development of new dosage form of it. METHODS: The solubility of rifapentine in 11 solvents was determined by UV spectrophotome-try, and solubilization effects of 4 kinds of solubilizers on it were investigated. The apparent oil/water partition coefficients of hex-ane and n-caprylic alcohol were investigated, and the stability of it was determined under high temperature, high humidity and light. RESULTS: Rifapentine showed good solubility in chlorofoim with solubility of 13.076 mg·L‐1; it showed poor solubility in water with solubility of 3.046 mg·L‐1. Tween-80 played strong solubilization roles and the solubility was up to 823 mg·L‐1. The apparent oil/water partition coefficients in hexane and n-caprylic alcohol were 4.778 ± 0.41 and 17.441 2 ± 2.79. Color and the content of main components among stability index had changed. CONCLUSION: Rifapentine shows strong fat-solubility and poor water-solubility, and suitable solubilizer can improve the solubility of it. It is not stable under high temperature, high humidity and light.关键词
利福喷丁/溶解度/紫外分光光度法/稳定性Key words
Rifapentine/ Dissolutions UV spectrophotometry/ Stability分类
医药卫生引用本文复制引用
折胜利,罗兰,吕顺忠,古丽再努尔·吐尔逊,蒋岳华,宋兴华..利福喷丁的溶解性与稳定性考察[J].中国药房,2012,23(17):1556-1558,3.基金项目
新疆维吾尔族自治区自然科学基金资助项目(2010211A46) （2010211A46）
