中国药房2012，Vol.23Issue(17)：1582-1584,3.DOI:10.6039/j.issn.1001-0408.2012.17.16
牛磺酸对动脉粥样硬化模型兔的抗炎作用研究
Anti-inflammatory Effect of Taurine on Atherosclerosis Model Rabbits
孙宝岩 1祝焕林 2翟桂兰3
作者信息
- 1. 辽宁医学院,辽宁锦州 121000
- 2. 解放军205医院心内科,辽宁锦州121000
- 3. 辽宁医学院第一附属医院心内科,辽宁锦州121000
- 折叠
摘要
Abstract
OBJECTIVE: To study the anti-inflammatory effect of taurine on atherosclerosis model rabbits. METHODS: Rabbits were randomized into blank control group, model group, taurine high-dose and low-dose (4,2 g·d‐1) groups with 10 rabbits in each group. Blank control group were given normal feedstuff and other 3 groups were given fat feedstuff. At the same time, taurine groups were given relevant drugs. Those rabbits were sacrificed 12 weeks later. The morphological changes of aortic cells of rabbits were observed. The levels of M1F and IL-8 were determined by immuohistochemistry and TNF-a level was tested by enzyme-linked immunosorbent assay. RESULTS: Compared with blank control group, the thickness of aorta intima, thickness ratio of intima to tunica elastica, the expression of MIF, IL-8 and TNF-a increased insignificantly in other 3 groups (P<0.01). Compared with model group, above items of taurine high-dose and low-dose groups decreased significantly (P<0.01). CONCLUSION: The taurine has the ability of preventing atherosclerosis by its function on anti-inflammation factors, such as MIF, IL-8 and TNF-α.关键词
牛磺酸/兔/动脉粥样硬化/巨噬细胞移动抑制因子/白细胞介素8/肿瘤坏死因子αKey words
Taurine/ Rabbits/ Atherosclerosis/ Macrophage inhibitory factor/ Interleukin-8/ Tumor necrosis factor-α分类
医药卫生引用本文复制引用
孙宝岩,祝焕林,翟桂兰..牛磺酸对动脉粥样硬化模型兔的抗炎作用研究[J].中国药房,2012,23(17):1582-1584,3.
