中国药房2012，Vol.23Issue(22)：2059-2062,4.DOI:10.6039/j.issn.1001-0408.2012.22.15
艾塞那肽治疗对2型糖尿病患者缓解期的影响研究
Effects of Exenatide Treatment on Remission Period of Patients with Type 2 Diabetes
摘要
Abstract
OBJECTIVE: To investigate the effects of exenatide treatment on the remission period of patients with type 2 diabetes. METHODS: 57 patients with type 2 diabetes in endocrinology department of our hospital from Nov. 2009 to Oct. 2010 were included and divided into exenatide group (n=31) and control group (n=26) according to disease duration, body weight index, fasting postprandial C Peptide, blood lipid, previous treatment scheme. During follow-up, plasma glucose, HbA1c, serum insulin and C peptide were evaluated every month. Before treatment and after 3 month, 72 h dynamic glucose monitoring (DGM) and intravenous glucose tolerance test (IVGTT) were performed. RESULTS: In type 2 diabetics with the treatment of exenatide, 16.13% (n= 5) of them achieved remission, there was statistical significance between exenatide group and control group (P<0.05). Compared with before treatment, fasting blood glucose, postprandial blood glucose, HbA1C and the rate of hyperglycemia and hypoglycemia during DGM were significantly lowered after 3 months of treatment, there was statistical significance (P<0.05). CONCLUSION: Exenatide therapy can promote remission of patients with type 2 diabetes.关键词
艾塞那肽/2型糖尿病/缓解期/治疗Key words
Exenatide/ Type 2 diabetes/ Remission period/ Treatment分类
医药卫生引用本文复制引用
黄艾平,吴文字,熊璞,陈晶,王霞,张弛,陈丹丹,赵乃蕊,李华珠,杨晓春,周桂莲,冯晶,王敏..艾塞那肽治疗对2型糖尿病患者缓解期的影响研究[J].中国药房,2012,23(22):2059-2062,4.基金项目
湖南省科技计划项目(2011FJ4163) （2011FJ4163）
