摘要
Abstract
OBJECTIVE: To investigate the influence of different duration of sevofiurane inhalation on muscle relaxation effect of cisatracurium in children. METHODS: 60 children (2~8 years old, ASA Ⅰ ~ Ⅱ ) undergoing elective facial and neck surgery (cheiloplasty, palatorrhaphy and thyroglossal duct cyst excision) were divided into 30-min sevofiurane inhalation group (group S30), 60-min sevofiurane inhalation group (group S60) and total intravenous anesthesia group (group T) with 20 children in each group, according to drug use. After anesthesia, they were given intravenous injection of cisatracurium 0.15 mg·kg‐1, and group S30 and S60 were exposed to 2.5% sevofiurane after tracheal intubation for 30 min and 60 min while group T received total intravenous anesthesia. Those groups received a train-of-four (TOF) mode, and muscle relaxation monitor was used to monitor the muscle relaxation. Onset time (Tonsel), duration of peak effect(DURp), recovery index(RI), duration of clinical action(DURj, duration of total action (DUR,) and time to TOFR(T4/T1) 90% (TOFR0.9) were recorded. RESULTS: There was no significant difference in Tonset among the three groups (P>0.05). DUR,, DUR, and TOFR0.9 of group S30 and group S50 were significantly prolonged compared to group T (P<0.05). DUR,, DUR,, DUR, and TOFR0.9, of group S50 were significantly prolonged compared to group S30 (P<0.05). CONCLUSION: 2.5% sevoflurane can enhance the muscle relaxation effect of cisatracurium in children with increasing durations of inhalation. 60 min of sevoflurane inhalation may delay the spontaneous recovery, while 30 min or less of sevofiurane inhalation may not.关键词
七氟醚/顺式阿曲库铵/麻醉药/吸入/神经肌肉阻滞/儿童Key words
Sevoflurane/ Cisatracurium/ Anesthetics/ Inhalation/ Neuromuscularblockade/ Children
分类
医药卫生
