中国药房2012，Vol.23Issue(23)：2113-2116,4.DOI:10.6039/j.issn.1001-0408.2012.23.01
双藤巴布剂中青藤碱、雷公藤甲素的体外释放与体外透皮机制研究
Study on Vitro Release and Transdermal Mechanism of Sinomenine and Triptolide in Shuangteng Cataplasm
摘要
Abstract
OBJECTIVE: To study in vitto release and transdermal mechanism of sinomenine and triptolide in Shuangteng cataplasm, and to compare the release rate and transdermal velocity of chemical components as potion ingredients (sinomenine and triptolide cataplasm, STP) and extracrum as potion ingredients (cataplasm of extracts from caulis sinomenii and tripterygium wilfordii, STEP). METHODS: In vitro release rate was determined by release rate detection; in vitro transdermal property of drugs was detected by Franze diffusion cell, and skin of nude mice back was used for test. RESULTS: In vitro drug release of sinomenine and triptolide in STP and STEP were in line with Higuchi equation (STP: r()=0.995 5, r() 0.995 8 j STEP: r()= 0.992 0, r().=0.996 3).The transdermal process was in accordance with zero-level equation (STP:r()=0.995 l,r()=0.994 2;STEP: r()=0.992 6,r()=0.990 2). The transdermal velocity constants were 21.729 μg·cm-2·h-1 and 0.478 3 μg·cm-2·h-1,20.063 μg·cm-2·h-1 and 0.416 8 ug·cm-2·h-1 respectively. CONCLUSION: Release rate of sinomenine and triptolide in STP or STEP in vitro is higher than transdermal velocity of them, and they are transdenn delivery preparation correlated to skin permeation.关键词
青藤碱/雷公藤甲素/体外透皮/体外释放Key words
Sinomenine/ Triptolide/ In vitro transdermal/ In vitro release分类
医药卫生引用本文复制引用
邓亚利,周莉玲..双藤巴布剂中青藤碱、雷公藤甲素的体外释放与体外透皮机制研究[J].中国药房,2012,23(23):2113-2116,4.基金项目
国家自然科学基金资助项目(30672669) （30672669）
