川芎嗪联合丹参酮ⅡA对缺血再灌注大鼠肺损伤的保护作用研究OACSCDCSTPCD
Protective Effect of Ligustrazine Combined with Tanshinone Ⅱ A on Lung Injury in Rats with Ischemia-reperfusion Injury
目的:研究川芎嗪联合丹参酮ⅡA对缺血再灌注大鼠肺损伤的保护作用.方法:实验分为空白对照(等容生理盐水)、假手术(等容生理盐水)、模型(等容生理盐水)、地塞米松(5mg·kg-1)和川芎嗪+丹参酮ⅡA高、中、低剂量(40+12、20+6、10+3mg·kg-1)组.于肺缺血前3d灌胃给药,每天1次.测定大鼠血浆丙二醛(MDA)含量、肺匀浆髓过氧化物酶(MPO)活性、湿重/干重比值(W/D)和肺通透指数.结果:与空白对照组比较,模型组大鼠血浆MDA含…查看全部>>
OBJECTIVE: To study the protective effect of ligustrazine combined with tanshinone II a on lung injury in rats with ischemia-reperfusion injury. METHODS: SD male rats were divided into 7 groups, I.e. Blank control group (constant volume of normal saline), sham operation group (constant volume of normal saline), model group (constant volume of normal saline), dexa-methasone group (5 mg·kg-1), TMP+tanshinone ⅡA high-dose, medium-dose and low-dose groups (40+12…查看全部>>
韩敏珍;冉群钗
贵阳医学院第二附属医院,贵阳556000贵阳医学院第二附属医院,贵阳556000
医药卫生
大鼠缺血再灌注肺损伤川芎嗪丹参酮ⅡA
Rat Ischemia reperfusion Lung injury Ligustrazine Tanshinone Ⅱa
《中国药房》 2012 (23)
2125-2127,3
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