中国医科大学学报2012，Vol.41Issue(5)：431-434,4.
胃癌组织中ATBF1蛋白的表达及临床病理意义
Clinicopathological Significance of ATBF1 Expression in Gastric Carcinoma
摘要
Abstract
Objective To observe the role of ATBF1 expression in and explore relevant mechanisms of tumorigenesis and progression of gastric cancer. Methods Formalin-fixed and paraffin-embedded tissues of gastric cancer (n =85) and adjacent non-neoplastic mueosa (NNM n =84) were studied with tissue microanay for ATBF1 expression using 4 antibodies (NT440,1-12,D1-120 and AT6) by immuno-histochemistry. ATBF1 expression was compared with clinicopathological parameters of tumois,including expression of ki-67 protein. Results The positive rates of cytoplasmic NT440 and AT6 expression were lower in gastric cancers than that in the NNMs (P < 0.05), while nuclear NT440 expression showed otherwise (P < 0.05). There was higher expression of D1-120 and AT6 in elder than younger patients with gastric cancer (P< 0.05). Dl-120 expression was positively correlated with lymph node metastasis (P< 0.05),which was the same for AT6 expression and angiolymphatic invasion (P< 0.05). It was worth noting that 1-12 expression of ATBF1 showed close association with the ki-67 expression in gastric cancer (P < 0.05). Conclusion Aberrant ATBF1 expression or its translocarion from cytoplasm to nuclear might play an important role during gastric carcinogenesis. ATBF1 expression is involved in local invasion and lymph node metastasis of gastric carcinomas, possibly via regulation of cellular proliferation.关键词
胃癌/ATBF1/癌发生/演进/增殖Key words
gastric cancer/ ATBF1/ carcinogenesis/ progression/ proliferation分类
医药卫生引用本文复制引用
王建平,勾文峰,川口诚,高野康雄,郑华川..胃癌组织中ATBF1蛋白的表达及临床病理意义[J].中国医科大学学报,2012,41(5):431-434,4.基金项目
国家自然科学基金资助项目(81172371) （81172371）
