中国医科大学学报2012，Vol.41Issue(5)：454-457,4.
脂联素基因多态性与新疆地区哈萨克族2型糖尿病的相关性研究
Correlation of 45T/G Polymorphism Adiponectin Gene with Type 2 Diabetes in Kazaks of Xinjiang
康小龙 1唐孝龙 2何承辉3
作者信息
- 1. 新疆医科大学附属中医医院药研室,乌鲁木齐830000
- 2. 新疆医科大学第一附属医院康复科,乌鲁木齐830000
- 3. 新疆药物研究所药剂室,乌鲁木齐830004
- 折叠
摘要
Abstract
Objective To investigate the association of adiponectin single nucleonde polymorphism (SNP) 45T/G with the prevalence of type 2 diabetes mellitus (T2DM) in Kazaks of the Xinjiang region, China. Methods Trie case-control study was employed. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to determine the distribution of allele and genotype frequency of the SNP45 T/G polymorphism (exon 2) in the adiponectin gene. ELISA was used to determine plasma adiponectin levels. And many anthropometric and biological indices were compared in different genotype carriers. Results The distribution of genotype and allele frequencies of the SNP45 were not statistically different between T2DM and NGT groups (P > 0.05). There was also no significant difference in plasma adiponectin concentrations between TT genotype and TG+GG genotype between T2DM and NGT groups (P > 0.05). Compared with SNP45 T carriers,in the NGT group,G carriers had higher body mass index,ratio of waist and Hip, waist circumference,triglyceride,low density lipoprotein and total cholesterol (P < 0.05),and lower levels of high-density lipoprotein (P < 0.01). Conclusion SNP45 in adiponectin gene is not associated with T2DM in Kazaks population of Xinjiang.关键词
脂联素基因/单核苷酸多态性/2型糖尿病/哈萨克族Key words
adiponectin gene/ single nucleotide polymorphism 45 T/G/ type 2 diabetes/ Kazaks分类
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康小龙,唐孝龙,何承辉..脂联素基因多态性与新疆地区哈萨克族2型糖尿病的相关性研究[J].中国医科大学学报,2012,41(5):454-457,4.
