中国药理学通报2012，Vol.28Issue(8)：1049-1053,5.DOI:10.3969/j.issn.1001-1978.2012.08.04
EGCG对阿尔采末病的保护作用研究进展
Research progress on the protective effect of EGCG on Alzheimer's disease
摘要
Abstract
Epigaloctechin-3-gallit (EGCG) is a highly effective antioxidant. It improves Alzheimer' s disease ( AD) by the way oi restoring the delect and quantity of brain nicotinic cholinergic receptors, reducing the level oi C-Ab1 protein, a nuclear transier oi nonreceptor tyrosine kinase, impeding the activation of β-iso-iorms oi glycogen synthesis kinase 3 ( GSK-3 β ) , opposing oxidation, improving mitochondrial dysiunction and acting on it like estrogen. As a result, it strengthens the clearance to Aβ by reducing the cytotoxicity oi neuron and by down-regulating the expression of Amyloid precusor protein (APP) so as to protect the iunction of Alzheimer' s neuron.关键词
EGCG/阿尔采末病/清除Aβ作用/烟碱型胆碱能受体/C-Abl蛋白/β-亚型糖原合成激酶3Key words
EGCG/ Alzheimer' s disease/Aβ clearance/nicotinic cholinergic receptors/ C-Abl protein/ β-isoiorms oi glycogen synthesis kinase 3分类
医药卫生引用本文复制引用
刘志男,林原,唐泽耀..EGCG对阿尔采末病的保护作用研究进展[J].中国药理学通报,2012,28(8):1049-1053,5.基金项目
国家自然科学基金资助项目(30772601) （30772601）
