中国药理学通报2012，Vol.28Issue(8)：1150-1152,3.DOI:10.3969/j.issn.1001-1978.2012.08.025
幼猪心肌梗死后植入骨髓间充质干细胞对心室肌细胞复极活动的影响
Effect of mesenchymal stem cell implantation in post infarctioned swine myocardium on repolarization of cardiomyocytes in left ventricle
摘要
Abstract
Aim To investigate the effect of mesenchymal stem cell implantation in post infarctioned swine myocardium on repolarization of cardiomyocytes in left ventricle. Methods Ten swines were used as normal controls ( control group) , 23 swines with acute myocar-dial infarction ( AMI) received intracoronary infusion of either MSC solution( MSC group, re = 13 ) or 0. 9% sodium chloride solution ( MI group, re = 10). 6 weeks later, monophasic action potentials ( MAPs) were recorded from left ventricular endocardium for the analyses of action potential duration of 90% repolarization (APD90) , repolarization time ( RT) , dispersion of APD and RT (APDd and TRd) , slope of APD reconstitution curve and critical cycle of APD alternans. Results (1) The values of APD90 , APDd, RT and RTd in the MI and MSC groups markedly increased compared with Control group (all P < 0. 01 ). However, those in the MSC group were significantly lower than MI group ( all P < 0. 05). (2) Only the slope of reconstitution cuvre in the control group was normal ( < 1 ) , but that in the MSC grope was apparently less than MI group. (3) The critical cycle length of APD alternans in the MSC group was remarkably higher than that in the control group (P <0. 01) and lower than that in the MI group (P < 0. 05). Conclusion Increased repolarization dispersion in left ventricle can be relieved by MSC implantation, so MSC-based therapy may be expected to reduce the increased risk of ventricular arrhythmias caused by MI.关键词
骨髓间充质干细胞/移植/心肌梗死/动作电位/电交替/室性心律失常Key words
mesenchymal stem cell/ implantation/ myocardial infarction/ action potential/ electrical alternans/ venrticular arrhythmia分类
医药卫生引用本文复制引用
王星,陈月云,王德国,邢文,李祥东,汪源经,王安才..幼猪心肌梗死后植入骨髓间充质干细胞对心室肌细胞复极活动的影响[J].中国药理学通报,2012,28(8):1150-1152,3.基金项目
安徽省教育厅自然科学基金资助项目(No 2009KJB161 HSP-70) （No 2009KJB161 HSP-70）
