中国药理学与毒理学杂志2012，Vol.26Issue(3)：263-268,6.DOI:10.3867/j.issn.1000-3002.2012.03.002
P2X4受体结构及其参与神经病理性痛机制的研究进展——对新药研发的启示
Advances for the structure and possible role of P2X4 receptor in the development of neuropathic pain: implication for new drug discovery
苏瑞斌1
作者信息
- 1. 军事医学科学院毒物药物研究所,北京100850
- 折叠
摘要
Abstract
Neuropathic pain is a kind of chronic pain after neuro-inflammation or neuro-trauma, the mechanisms of which are complex. Till now there is no effective drug for the treatmet of neuropathic pain. In recent years, great progress has been made about the protein structure of P2X4 receptor and the important region for ligand binding. In addition, it was proved that the P2X4 receptor expressed on the spinal microglia exerted important role in the development of neuropathic pain which infer the participation of P2X4 receptor in neuropathic pain. In this article, we reviewed the advances made in the recent years about the structure and possible role of P2X4 receptor in the development of neuropathic pain and hope to provide new ideas to develop new drugs target P2X4 receptor.关键词
P2X4受体/神经病理性痛/小胶质细胞Key words
P2X4 receptor/ neruopathic pain/ microglia分类
医药卫生引用本文复制引用
苏瑞斌..P2X4受体结构及其参与神经病理性痛机制的研究进展——对新药研发的启示[J].中国药理学与毒理学杂志,2012,26(3):263-268,6.
