中国药理学与毒理学杂志2012，Vol.26Issue(3)：379-382,4.DOI:10.3867/j.issn.1000-3002.2012.03.023
N-甲基-D-天冬氨酸受体激活在脑缺血中的神经保护及神经毒性作用研究进展
Role of N-methyl-D-aspartate receptors activation in neuronal survival and excitotoxicity in brain ischemia
骆媛 1王永安1
作者信息
- 1. 军事医学科学院毒物药物研究所军事毒理与生化药理研究室,北京100850
- 折叠
摘要
Abstract
N-Methyl-D-aspartate (NMDA ) receptor-mediated excitotoxicity in neuronal damage is a key pathological factor of ischemic brain injury. However, NMDA receptor activity at the physiological level can promote neuronal survival and resistance to trauma and play important roles in synaptic plasticity and transmission. This dichotomy may explain the poor tolerance and efficacy of NMDA receptor antagonists in clinical trials for excitotoxic trauma. Understanding of signaling events that mediate the opposing effects of NMDA receptor activity is important and may lead to therapeutic strategies that enable the selective blockade of pro-death signaling while sparing physiological signaling to survival and plasticity. In this review, the current understanding of the role of NMDA receptor and its pro-survival or pro-death signaling in ischemic brain injury are discussed.关键词
受体/N-甲基-D-天冬氨酸/信号通路/脑缺血/神经毒性Key words
receptor/N-methyl-D-aspartate/ signaling pathway/ brain ischemia/ neurotoxicity分类
医药卫生引用本文复制引用
骆媛,王永安..N-甲基-D-天冬氨酸受体激活在脑缺血中的神经保护及神经毒性作用研究进展[J].中国药理学与毒理学杂志,2012,26(3):379-382,4.
