中国药理学与毒理学杂志2012，Vol.26Issue(3)：402-405,4.DOI:10.3867/j.issn.1000-3002.2012.03.028
细胞色素氧化酶P450家族在中药毒性研究中的应用进展
Progress in cytochrome P450 enzyme in toxicity of traditional Chinese medicines
摘要
Abstract
Cytochrome P450(CYP) enzyme is one of the most important drug metabolism enzymes. Herbs can inhibit or induce the activity of CYP subtypes (CYP3A and CYP2C, etc). The inhibitory effect on drug metabolism is the main cause of adverse drug reactions. It has been found that CYP, including CYP1A2 and CYP2E1, meta-bolically activate toxicants. CYP affects drug metabolic interactions, which has been used to explore toxicity of Chinese herbal compatibility or incompatibility. The study on CYP activities in adverse drug reactions of Chinese herbs combined with Western medicine is of great important. This paper reviews the application of CYP in studies on the toxicity of traditional Chinese medicines.关键词
细胞色素P450酶系统/中草药/毒性作用Key words
cytochrome P-450 enzyme sysytem/ drugs, Chinese herbal/ toxic actions分类
医药卫生引用本文复制引用
廖乃顺,陈文列..细胞色素氧化酶P450家族在中药毒性研究中的应用进展[J].中国药理学与毒理学杂志,2012,26(3):402-405,4.基金项目
陈可冀中西医结合发展基金(CKJ2010034) （CKJ2010034）
