中国药业2012，Vol.21Issue(10)：55-56,2.
莫西沙星阴道泡腾片的制备和稳定性考察
Study on Preparation and Stability of Moxifloxacin Vaginal Effervescent Tablets
陈惠英 1张丹霞 1廖朝峰1
作者信息
- 1. 广东省深圳市宝安区人民医院药剂科,广东深圳518101
- 折叠
摘要
Abstract
Objective To prepare and observe the stability of moxifloxacin vaginal effervescent tablets so as to determine its expiry date. Methods The change of color, PH value and moxifloxacin content were detected through the trials of the influence factors including sunlight,high and low temperatures as well as the samples observation under the room temperature. The content of moxifloxacin was measured by high performance liquid chromatography (HPLC).The analysis was performed on a NOVa-PaRCis column (50 mm×3. 9 mm, 4 μm) with the mobile phase of 1% Iriethylamine (adjusted pH to 4.5 with phosphoric acid) -acetonitrile (84 : 16) at the flow rate of 1.0 mL/min and 296 nm as the detection wavelength. Results During the concentrations of 5-75 μg/mL, moxifloxacin showed good linear relationship with the peak area, r = 0.998 8( n = 6). The average recovery rate was 99.26% , RSD 0.58% (n = 5).The products were susceptible to sunlight. The content remained above 92.96% in the 1 - year observation test of the sample under the room temperature. Conclusion The preparation has a reasonable prescription with an expiry date more than 2 years.关键词
莫西沙星/高效液相色谱法/阴道泡腾片/稳定性Key words
moxifloxacin/ HPLC/ vaginal effervescent tablets/ stability分类
医药卫生引用本文复制引用
陈惠英,张丹霞,廖朝峰..莫西沙星阴道泡腾片的制备和稳定性考察[J].中国药业,2012,21(10):55-56,2.
