中国药业2012，Vol.21Issue(14)：44-46,3.
牛黄清心丸(局方)中朱砂和雄黄的含量测定
Determination of Cinnabar and Realgar in Niuhuang Qingxin Pills (Pharmacopoeia)
吴辉彬 1陈志成 2王晓云 2解庆东1
作者信息
- 1. 南方医科大学南方医院,广东,广州,510515
- 2. 中国人民解放军广州疗养院,广东,广州,510515
- 折叠
摘要
Abstract
Objective To establish a determination method of cinnabar and realgar in Niuhuang Qingxin Pills (Pharmacopoeia). Methods Niuhuang Qingxin Pills was firstly nitrified. The main components mercuric sulfide and arsenic disulfide in cinnabar and realgar in the preparation were performed the quantitative analysis by the oxidation - reduction titration with ammonium thiocyanate and iodine titration solutions respectivey. Results Mercury sulfide showed good linear relation in the range of 19.8-99 mg with the consumption volume of ammonium thiocyanate titrant,the regression equation Y = 85. 5 X + 0. 046( r = 0.999), the average recovery rate was 101. 07% with RSD of 2. 21% ,the mercuric sulfide content was 57. 75 mg per pill. Arsenic disulfide showed in good linear relation in the range of 9. 5 -47. 5 mg with the consumption volume of iodine titrant ,the regression equation Y = 171. 83 X - 0. 050 9( r = 0. 999 ),the average recovery rate was 101. 08% , RSD 1. 10% , the arsenic disulfide content was 22. 91 mg per pill. Conclusion The established method is reliable,highly accurate,strongly specific and can further control the contents of the toxic ingredients in the preparation.关键词
牛黄清心丸/朱砂/雄黄/含量测定Key words
Niuhuang Qingxin Pills/cinnabar/realgar/determination分类
医药卫生引用本文复制引用
吴辉彬,陈志成,王晓云,解庆东..牛黄清心丸(局方)中朱砂和雄黄的含量测定[J].中国药业,2012,21(14):44-46,3.
