首页|期刊导航|中华医学杂志（英文版）|Efficacy of pegylated interferon-alpha-2a plus ribavirin for patients aged at least 60 years with chronic hepatitis C
中华医学杂志（英文版）Issue(11)：1852-1856,5.DOI:10.3760/cma.j.issn.0366-6999.2012.11.002
Efficacy of pegylated interferon-alpha-2a plus ribavirin for patients aged at least 60 years with chronic hepatitis C
Efficacy of pegylated interferon-alpha-2a plus ribavirin for patients aged at least 60 years with chronic hepatitis C
摘要
Abstract
Background In China,patients with hepatitis C virus (HCV)-associated liver disease are getting older,and thus the number of deaths due to such disease is increasing.The efficacy of combination therapy with ribavirin and interferon for chronic HCV infection in elderly patients has not been fully clarified.The aim of the present study was to evaluate the efficacy and tolerability of the combination therapy in the elderly patients.Methods Sixty-eight chronic hepatitis C patients,who received the combination therapy,were classified into two age groups:elderly group (＞60 years,n=25) and non-elderly group (＜60 years,n=43).Rapid virological response,complete early virological response,sustained virological response,relapse,non-response rate,and safety were compared between the elderly group and non-elderly group.Results Overall sustained virological response was lower in the elderly group than non-elderly group (44％ vs.75％,P=0.012,OR=0.270,and 95％ C/ 0.095-0.768).Among patients with HCV genotype 1,sustained virological response was lower in the elderly group than non-elderly group (45％ vs.77％,P=0.015,OR=0.247,95％ C/ 0.078-0.781).The proportions of dose reduction due to laboratory abnormalities were significantly higher in the elderly group than non-elderly group (60.0％ vs.32.6％,P=0.027).Multiple binary Logistic regression analysis confirmed that patient age was an associated factor for sustained virological response.Conclusion Among patients with HCV genotype 1,the elderly patients had lower sustained virological response than non-elderly patients during pegylated interferon-alpha-2a plus ribavirin combination therapy.关键词
interferon/therapeutics/hepatitis C/agedKey words
interferon/therapeutics/hepatitis C/aged引用本文复制引用
ZHENG Ying-ying,FAN Xiao-hong,WANG Li-feng,TIAN Di,HUO Na,LU Hai-ying,WU Chi-hong,XU Xiao-yuan,WEI Lai..Efficacy of pegylated interferon-alpha-2a plus ribavirin for patients aged at least 60 years with chronic hepatitis C[J].中华医学杂志（英文版）,2012,(11):1852-1856,5.基金项目
This study was supported by the grants from the National Major Project for Infectious Diseases Control (No.2008ZX10002-013),the National Natural Science Foundation of China (No.30771906),and the PhD Programs Foundation of Ministry of Education of China (No.20090001110081). （No.2008ZX10002-013）
