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Steady-state pharmacokinetics of zidovudine in Chinese HIV-infected patients

LIU Li-feng WANG Lu FU Qiang ZHU Zhu XIE Jing HAN Yang LIU Zheng-yin YE Min LI Tai-sheng

中华医学杂志（英文版）Issue(11)：1931-1935,5.

中华医学杂志（英文版）Issue(11)：1931-1935,5.DOI:10.3760/cma.j.issn.0366-6999.2012.11.017

Steady-state pharmacokinetics of zidovudine in Chinese HIV-infected patients

LIU Li-feng ¹WANG Lu ²FU Qiang ²ZHU Zhu ³XIE Jing ³HAN Yang ²LIU Zheng-yin ²YE Min ²LI Tai-sheng³

作者信息

1. Chinese Academy of Medical Sciences, STD/AIDS Research Center, Beijing You An Hospital, Capital Medical University,Beijing 100071, China
2. Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China
3. Department of Pharmacology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China
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摘要

Abstract

Background The pharmacokinetics of zidovudine (AZT) are possibly influenced by weight,age,sex,liver and renal functions,severity of disease,and ethnicity.Currently,little information is available on the steady-state pharmacokinetics of AZT in Chinese HIV-infected patients.The current study aimed to characterize the steady-state pharmacokinetics of AZT in a Chinese set-up.Methods Eleven Chinese HIV-infected patients were involved in the steady-state pharmacokinetic study.In total,300 mg of AZT,as a part of combination therapy,was given to patients,and serial blood samples were collected for 12 hours.The samples were measured by a high-performance liquid chromatography (HPLC) assay,and the results were analyzed by both the non-compartment model and the one-compartment model.Results The Cmax of AZT in Chinese patients was higher than that in non-Asian patients.The half-life of AZT,analyzed by the non-compartment model (P=0.02),in male patients ((1.02±0.22) hours) was shorter than that of AZT in female patients ((1.55±0.29) hours).The AZT clearance,analyzed by the one-compartment model (P=0.045),in male patients ((262.60±28.13) L/h) was higher than that in female patients ((195.85±60.51 ) L/h).Conclusion The present study provides valuable information for the clinical practice of AZT-based highly active antiretroviral therapy in a Chinese set-up.

关键词

human immunodeficiency virus/steady-state/pharmacokinetics/zidovudine/Chinese patients

Key words

human immunodeficiency virus/steady-state/pharmacokinetics/zidovudine/Chinese patients

引用本文复制引用

LIU Li-feng,WANG Lu,FU Qiang,ZHU Zhu,XIE Jing,HAN Yang,LIU Zheng-yin,YE Min,LI Tai-sheng..Steady-state pharmacokinetics of zidovudine in Chinese HIV-infected patients[J].中华医学杂志（英文版）,2012,(11):1931-1935,5.

基金项目

This study was supported by the grants from the National Key Technologies R&D Program for the 11th Five-year Plan (No.2008ZX10001-006) and the National Natural Science Foundation of China (No.81071372). （No.2008ZX10001-006）

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