中华医学杂志（英文版）Issue(11)：2076-2079,4.DOI:10.3760/cma.j.issn.0366-6999.2012.11.044
JAK2 V617F positive essential thrombocythemia developing in a patient with CD5-chronic lymphocytic leukemia
JAK2 V617F positive essential thrombocythemia developing in a patient with CD5-chronic lymphocytic leukemia
WEI Ju 1WANG Chun 1QIN You-wen 2ZHU Jun 1GAO Yang-rong 1CAI Qi 1YAN Shi-ke1
作者信息
- 1. Department of Hernatology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
- 2. Laboratory of Hematology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
- 折叠
摘要
Abstract
Coexistence of chronic lymphocytic leukemia (CLL) and essential thrombocythemia (ET) in a patient is extremely rare,with only 10 cases reported thus far in literature.This paper describes a 94-year-old male having atypical B-CLL with CD5- (CD5-) phenotype and ET.In this patient,we performed interphase fluorescence in situ hybridization (FISH) analysis which revealed 13q14.3 deletion in 31％ of B-lymphocyte nuclei and RB1 deletion in 27％ of B-lymphocyte nuclei,but not in neutrophils and T-lymphocytes.Furthermore,we identified JAK2 V617F mutation in the peripheral blood nucleated cells and neutrophils,but not in the B- and T-lymphocyte populations.Therefore,it was concluded that the occurrence of CD5- B-CLL and ET in this patient was pathogenically independent.关键词
essential thrombocythemia/chronic lymphocytic leukemia/JAK2 V617F mutation/CD5-/fluorescence in situ hybridizationKey words
essential thrombocythemia/chronic lymphocytic leukemia/JAK2 V617F mutation/CD5-/fluorescence in situ hybridization引用本文复制引用
WEI Ju,WANG Chun,QIN You-wen,ZHU Jun,GAO Yang-rong,CAI Qi,YAN Shi-ke..JAK2 V617F positive essential thrombocythemia developing in a patient with CD5-chronic lymphocytic leukemia[J].中华医学杂志（英文版）,2012,(11):2076-2079,4.
