首页|期刊导航|中华医学杂志（英文版）|Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia
Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia
XU Pei-pei WANG Xue-mei XU Ke Margaret Schultz CHEN Bao-an FENG Ji-feng CHENG Lu XIA Guo-hua LI Yu-feng QIAN Jun DING Jia-hua LU Zu-hong
中华医学杂志（英文版）2012，Vol.125Issue(12)：2137-2143,7.
中华医学杂志（英文版）2012，Vol.125Issue(12)：2137-2143,7.DOI:10.3760/cma.j.issn.0366-6999.2012.12.011
Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia
Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia
摘要
Abstract
Background The cytosine arabinoside (Ara-C)-based chemotherapy is the major remedial measure for acute myeloid leukemia (AML).Deoxycytidine kinase (DCK) and cytidine deaminase (CDA) are the key enzymes in the metabolism ofAra-C.Many single nucleotide polymorphisms (SNPs) and haplotypes of DCK and CDA,which contribute to susceptibility to Ara-C,have been identified in Africans and Europeans.However,there has been no report about the relation among three SNPs in DCK (rs115543896,rs72552079,and rs111454937) and two SNPs in CDA (rs2072671 and rs60369023),and their clinical response to Ara-C for a Chinese population.In this study,we aimed to investigate whether these five SNPs are associated with the therapeutic outcomes of Ara-C-based chemotherapy regimens in patients with AML.Methods A total of 151 Chinese patients with AML were enrolled in our study.SNPs genotyping were performed using the MassARRAY system by means of the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) method.Results The results illustrated that DCKrs111454937 AA genotype was more frequent in patients with higher platelet count,and A allele frequency was significantly higher in the group ≤40 years,lower white blood ceil (WBC) count patients group and the group with platelet counts ＞60×109/L.Meanwhile,both DCKrs72552079 TC (OR=1.225,95％ Cl=1.225-9.851,P=0.0192) and CDArs60369023 GA (OR=9.851,95％ Cl=1.31-77.93,P=0.0263) significantly improved Ara-C-based chemotherapy response.While DCKrs11554389 AA (OR=0.147,95％ Cl=0.027-0.801,P=0.0267) wasassociated with the decrease of Ara-C-based chemotherapy response.Conclusion It is evident that the DCK and CDA polymorphisms might be the important markers for the AML patients' therapy outcomes in a Chinese population.关键词
deoxycytidine kinase/cytidine deaminase/single nucleotide polymorphisms/acute myeloid leukemiaKey words
deoxycytidine kinase/cytidine deaminase/single nucleotide polymorphisms/acute myeloid leukemia引用本文复制引用
XU Pei-pei,WANG Xue-mei,XU Ke,Margaret Schultz,CHEN Bao-an,FENG Ji-feng,CHENG Lu,XIA Guo-hua,LI Yu-feng,QIAN Jun,DING Jia-hua,LU Zu-hong..Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia[J].中华医学杂志（英文版）,2012,125(12):2137-2143,7.基金项目
This work was supported by the grants from the National Key Basic Research Program 973 of China (No.2010CB732404),the National Natural Science Funds of People's Republic of China (No.81170492),the Key Medical Disciplines of Jiangsu Province,and the Graduate Research and Innovation Program of Jiangsu Province (No.CXLX_0150). （No.2010CB732404）
