中华医学杂志（英文版）2012，Vol.125Issue(12)：2219-2224,6.DOI:10.3760/cma.j.issn.0366-6999.2012.12.024
Gene delivery in peritoneal dialysis related peritoneal fibrosis research
Gene delivery in peritoneal dialysis related peritoneal fibrosis research
LI Xie-jia 1SUN Lin 1XIAO Li 1LIU Fu-you1
作者信息
- 1. Department of Nephropathy,Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China
- 折叠
摘要
Abstract
Objective To summarize the development of gene delivery vectors in peritoneal fibrosis research and discuss the feasibility and superiority of lentiviral vectors.Data sources The data in this article were collected from PubMed database with relevant English articles published from 1995 to 2011.Study selection Articles regarding the gene therapy in peritoneal fibrosis research using non-viral vectors,adenoviral vectors,ratroviral vectors,and lentiviral vectors were selected.Data were mainly extracted from 60 articles,which are listed in the reference section of this review.Results Non-viral vector-mediated gene delivery (including naked DNA for ex vivo,oligonucleotides,ultrasoundcontrast agent mediated naked gene delivery,etc.) and viral vector-mediated gene delivery (including adenovirus,helper-dependant adenovirus,and retrovirus vectors) have been successfully applied both in the mechanistic investigation and the potential prevention and treatment of peritoneal fibrosis.Conclusions Peritoneal fibrosis is a major complication of peritoneal dialysis (PD).Recently,the wide use of the gene delivery technique made it possible to access and further research peritoneal fibrosis.The use of lentiviral vector is expected to be widely used in PD research in the future due to its advantages in gene delivery.关键词
peritoneal dialysis/peritoneal fibrosis/gene delivery/non-viral vector/viral vectorKey words
peritoneal dialysis/peritoneal fibrosis/gene delivery/non-viral vector/viral vector引用本文复制引用
LI Xie-jia,SUN Lin,XIAO Li,LIU Fu-you..Gene delivery in peritoneal dialysis related peritoneal fibrosis research[J].中华医学杂志（英文版）,2012,125(12):2219-2224,6.
