中华临床免疫和变态反应杂志2012，Vol.6Issue(2)：152-157,6.
药物过敏发病机制及体内外检测
Pathogenesis, in Vivo and in Vitro Test of Drug Allergy
杨林 1刘光辉1
作者信息
- 1. 华中科技大学 同济医学院附属同济医院过敏反应科,武汉430030
- 折叠
摘要
Abstract
"Drug allergy" refers to immunological mechanism-mediated drug hypersensitivity reactions, which may be either IgE-mediated (immediate) or non-IgE mediated (delayed) hypersensitivity reactions. Small molecular drug can induce immune response by binding to carrier protein as prototype or metabolism product, and even can directly bind to T cell antigen receptor to activate CD4 + T cells or CD8 + T cells. Drug can induce type I to ]V hypersensitivity reactions after recognized by immune system. The main detection methods of drug allergy include in vivo skin tests, in vitro laboratory teats and drug provocation tests.关键词
药物过敏/皮肤试验/特异性IgE/嗜碱性粒细胞/激发试验Key words
drug allergy/ skin test/ specific-IgE/ basophils/ provocation test分类
医药卫生引用本文复制引用
杨林,刘光辉..药物过敏发病机制及体内外检测[J].中华临床免疫和变态反应杂志,2012,6(2):152-157,6.
