肿瘤防治研究2012，Vol.39Issue(4)：417-420,4.DOI:10.3971/j.issn.1000-8578.2012.04.012
非黏液型细支气管肺泡癌与肺腺癌组织中VEGF-C的表达及临床意义
Expression of VEGF-C in Nonmucinous Bronchioalveolar Carcinoma and Pulmonary Adenocarcinoma Tissues
摘要
Abstract
Objective To discuss invasiveness and metastasis of nonmucinous bronchioalveolar carcinoma. Methods Fourty-three cases with nonmucinous bronchioalveolar carcinoma were enrolled in experimental group,control group consisted of 17 cases of mucinous bronchioalveolar carcinoma,22 cases of pulmonary adenocarcinoma and 10 cases of lung tissue adjacent to nonmucinous bronchioalveolar carcinoma. Expression of VEGF-C protein and mRNA were detected using immunohistochemical method and RT-PCR,respectively. Results Positive rate of VEGF-C protein in nonmucinous bronchioalveolar carcinoma was significantly higher than that in lung tissue adjacent to nonmucinous bronchioalveolar carcinoma and mucinous bronchioalveolar carcinoma (P<0. 01), compared with pulmonary adenocarcinoma, the difference showed no statistical significance(P>0. 05) .node metastasis rate in nonmucinous bronchioalveolar carcinoma was significantly higher than that in mucinous bronchioalveolar carcinoma(P<0. 01), compared with pulmonary adenocarcinoma,the difference showed no statistical significance(P>0. 05). Twenty cases of nonmucinous bronchioalveolar carcinoma exhibited node metastasis, compared with non-metastasis group,positive rate of VEGF-C protein showed statistical significance(P<0. 05). Expression of VEGF-C mRNA in nonmucinous bronchioalveolar carcinoma was significantly higher than that in lung tissue adjacent to nonmucinous bronchioalveolar adenocarcinoma and mucinous bronchioalveolar carcinomaC P<0. 01), compared with pulmonary adenocarcinoma,it was dramatically lower(P<0.01). Conclusion Up-regulation of VEGF-C protein in nonmucinous bronchioalveolar carcinoma suggests that it may has similar invasiveness and metastasis characteristic with pulmonary adenocarcinoma, compared with mucinous bronchioalveolar carcinoma, node metastasis more easily occured in nonmucinous bronchioalveolar carcinoma.关键词
非黏液型细支气管肺泡癌/VEGF-C/转移/侵袭性Key words
Nonmucinous bronchioalveolar carcinoma/VEGF-C/ Metastasis)Invasiveness分类
医药卫生引用本文复制引用
邹亮,雷浪,石丹,汪庆余,邬黎青,冯琼,廖首生..非黏液型细支气管肺泡癌与肺腺癌组织中VEGF-C的表达及临床意义[J].肿瘤防治研究,2012,39(4):417-420,4.基金项目
江西省科技厅支撑计划资助项目(2009BSB11108) （2009BSB11108）
