肿瘤防治研究2012，Vol.39Issue(5)：511-514,4.DOI:10.3971/j.issn.1000-8578.2012.05.005
骨髓TPO及受体c-MPL表达变化在急性髓系白血病化疗中的意义
Significance of Expression of Marrow Thrombopoietin and Its Receptor c-MPL before and after Chemotherapy in Acute Myeloid Leukemia
摘要
Abstract
Objective To study the expression and the signification of marrow TPO and its receptor e-MPL in acute myeloid leukemia relapse after chemotherapy. Methods The expression of TPO and c-MPL of newly diagnosed acute myeloid leukemia patients before chemotherapy,complete remission after chemotherapy and its relapse was detected by using ELISA and flow cytometry.respectively. Results The expression of bone marrow TPO and c-MPL before chemotherapy was (162. 21 ± 39. 92)ng/ml and (6. 04 ± 4. 072)%,it was lower than the (213. 19 ± 48.34)ng/ml,(ll. 23 ± 5.225)% of relapse group siglificant-ly. The expression of bone marrow TPO and c-MPL before chemotherapy and relapse group were significantly higher than (122. 14 ± 25. 75)ng/ml, (2. 84 ± 0. 724) % of control group. The expression of bone marrow TPO and c-MPL of remission group was (115. 82 ± 22. 32)ng/ml and (2. 81 ± 1. 306) %. The expression of marrow TPO and c-MPL between chemotherapied AML patients and normal group was no significant difference(P>0. 05). The expression of bone marrow TPO was positively correlated with c-MPL. Conclusion (1 )The high expression of bone marrow TPO and its receptor c-MPL may be associated with the relapse of acute myeloid leukemia after treatment. (2) The expression of bone marrow TPO and c-MPL was significantly higher in relapse group than before chemotherapy. It suggested that TPO/c-MPL signaling pathway may play an important role in acute myeloid leukemia relapse and refractory after treatment.关键词
血小板生成素/血小板生成素受体/急性髓系白血病/化疗/复发Key words
Thrombopoietin/Thrombopoietin receptor/ Acute myeloid leukemia/Chemotherapy/Relapse分类
医药卫生引用本文复制引用
张勇,孔佩艳,曾东风,李杰平,彭贤贵,罗乐,李佳丽..骨髓TPO及受体c-MPL表达变化在急性髓系白血病化疗中的意义[J].肿瘤防治研究,2012,39(5):511-514,4.基金项目
国家自然科学基金青年基金资助项目(81000195) （81000195）
