肿瘤防治研究2012，Vol.39Issue(5)：532-534,3.DOI:10.3971/j.issn.1000-8578.2012.05.009
Gli1蛋白在乳腺癌组织中的表达及其与血管生成的关系
Expression of Gli1 Protein and Its Relation with Angiogenesis in Breast Carcinoma
摘要
Abstract
Objective To study the expression of Glil protein.a component of Hedgehog/Glil signal pathway,and its relationship with angiogenesis in human breast cancer. Methods The expression of Glil protein was investigated by immunohistohistochemical method in 79 cases of human breast cancer,68 cases of normal tissues adjacent to cancer and 42 cases of breast fibroadenoma tissues. The microvascular density (MVD) was examined by using immunohistochemical CD34 staining assay. Results The Glil expression was higher in breast carcinoma than that in adjacent normal tissues and in breast fibroadenoma(P<0. 05). Expression of Glil was significant higher in TNM stage Ⅲ than that in TNM stage Ⅰ ~ Ⅱ (P<0. 05) and also was higher with axillary lyrnphnode metastasis than without lymphnode metastasis(P<0. 05), Expressions of Glil were positively correlated with MVD(r= 0. 325,P<0. 05). Conclusion Glil protein is activated and plays an important role in development of breast cancer. Promoting angiogenesis might be one of its mechanisms.关键词
乳腺癌/Hedgehog信号通路/Gli1蛋白/血管生成Key words
Breast carcinoma/ Hedgehog signal pathway/Glil proteins Angiogenesis分类
医药卫生引用本文复制引用
张兰胜,陈冬波,贾晓民,王保庆,凌桂琴,张世强..Gli1蛋白在乳腺癌组织中的表达及其与血管生成的关系[J].肿瘤防治研究,2012,39(5):532-534,3.基金项目
江苏省徐州市科技计划基金资助项目(XF10C047) （XF10C047）
