肿瘤防治研究2012，Vol.39Issue(5)：538-541,4.DOI:10.3971/j.issn.1000-8578.2012.05.011
HER3在乳腺癌中的表达及临床意义
Expression and Clinical Significance of HER3 in Breast Carcinoma
张挺丽 1王彬 1吴锦昌 2周俊东 2张玲3
作者信息
- 1. 215001江苏苏州,苏州市立医院东区肿瘤内科
- 2. 215001江苏苏州,苏州市立医院东区放疗科
- 3. 215001江苏苏州,苏州市立医院东区肿瘤实验室
- 折叠
摘要
Abstract
Objective To investigate the relationships between the expression of HER3.HER2.ER and PR .and their effects on the clinical prognosis of human breast carcinoma. Methods The expressions of HER3,HER2,ER and PR were studied in 136 cases with breast carcinoma by using SP immunohisto-chemistry. The endpoint was overall survival(OS). Results HER2,HER3,ER and PR expression was detected in 136 cases with positive rates of 50% ,41. 18%,60. 9% and 27. 21% .respectively. The expression intensity of HER3 in breast carcinoma had no significant correlation with the age,lymph node metastasis, pathological types,TNM stage,chemotherapy of the patients(P>0. 05). Compared with those patients with HER3-negitive profiles,the patients with HER3-positive profiles had significantly lower OS(P = 0. 015). The patients with HER3( + ) HER2( + ) expression profiles had significantly lower OSCP = 0. 047) than other groups. There is no interaction between HER3 and PR expressionCP = 0. 214), but HER3 have a inverse relationship with ER expression(P = 0. 001). Overexpression of HER2 and HER3 was highly correlated (P = 0. 000). Conclusion HER3 expression is an independent predictor of breast cancer. Patients with HER3-negative have a longer OS.关键词
HER3/HER2/乳腺癌/免疫组织化学Key words
HER3/HER2/ Breast carcinoma/ Immunohistochemistry分类
医药卫生引用本文复制引用
张挺丽,王彬,吴锦昌,周俊东,张玲..HER3在乳腺癌中的表达及临床意义[J].肿瘤防治研究,2012,39(5):538-541,4.
