肿瘤防治研究2012，Vol.39Issue(5)：551-554,4.DOI:10.3971/j.issn.1000-8578.2012.05.014
Snail及N-cadherin蛋白在骨肉瘤中的表达及其与预后的关系
Expression and Prognosis Analysis of Snail and N-cadherin Protein in Osteosarcoma
刘宣毅 1贾卫斗 2侯瑞 2王焱2
作者信息
- 1. 075000河北张家口,河北北方学院研究生部
- 2. 中国人民解放军第251医院骨一科
- 折叠
摘要
Abstract
Objective To research the expressions of Snail and N-cadherin in osteosarcoma and to explore their roles in the carcinogenesis and progression of osteosarcoma. Methods Immunohistochemical assay (SP method) was used to detect the expressions of Snail and N-cadherin in 38 cases osteosarcoma tissues and 10 cases osteochondroma tissues. Results (1) Expression of Snail and N-cadherin in osteosarcoma was higher than that in osteochondroma,the comparative differences were significant(X2 = 27. 375,P< 0.0l.X2 =21.849,P<0. 01). (2) Expression of Snail in osteosarcoma were concerned with soft tissue involvement,Ennecking stage,and lung metastases ;and the comparative differences were significant(P< 0. 05). However, the expression of Snail in osteosarcoma were irrelevant with gender,age and mass site(P >0.05). The expression of N- cadherin was positively correlated with that of Snail(r= 0. 421,P<0. 05). (3) The survival rate of the patients with positive express of Snail and N-cadherin was significant lower than those with negative express of snail and N-cadherin protein in osteosarcoma; and the comparative differences were significant(P<0. 05). Conclusion The overexpression of Snail and N-cadherin in osteosarcoma means that they play synergetic roles in the process and metastases of osteosarcoma and poor prognosis.关键词
Snail/N-cadherin/骨肉瘤/免疫组织化学/顸后分析Key words
Snail / N-cadherin/ Osteosarcoma/ Immunohistochemical / Prognosis分类
医药卫生引用本文复制引用
刘宣毅,贾卫斗,侯瑞,王焱..Snail及N-cadherin蛋白在骨肉瘤中的表达及其与预后的关系[J].肿瘤防治研究,2012,39(5):551-554,4.
