肿瘤防治研究2012，Vol.39Issue(5)：573-576,4.DOI:10.3971/j.issn.1000-8578.2012.05.020
两种不同给药方式下表阿霉素治疗乳腺癌近期疗效观察
Evaluation of Two Administration Way on Curative Effects of Epirubicin in Treatment of Breast Cancer
杨润祥 1任宏轩 1聂建云 2刘林 1董超 1高春林 1庄莉 1姚萍1
作者信息
- 1. 650118昆明,云南省肿瘤医院昆明医学院第三附属医院内二科
- 2. 650118昆明,云南省肿瘤医院昆明医学院第三附属医院乳腺病科
- 折叠
摘要
Abstract
Objective To evaluate the curative effects of Epirubicin( EPI) administered by means of micro-pumping and intravenous dripping in patients with breast cancer of the Ⅲ and the Ⅳ phases. Methods A total of 67 cases that were pathologically diagnosed as the Ⅲ- and Ⅳ-phase breast cancer were recruited in this study. Patients were randomly divided into two groups and received the same dosage of Epirubicin (70 mg/m2),which was administered by micro-pumping(MP group,n = 33) and intravenous dripping(ID group,n=34),respectively. Chemotherapy repeated on a regular three-week cycle and observations of the curative effect were conducted in line with the WHO standard. Results Data from a total of 214 courses of chemotherapy were collected from the two groups of patients. All cases are assessable of their curative effects. In the MP group, 10 cases of Ⅲ phase were specified as 2 cases of CR,6 PR,2 SD.but none of PD. The average remedial ratio(RR) reached 80. 0%(8/10) and their disease control ratio(DCR) was 100. 0%(10/10). Of the 23 cases of the Ⅳ phase(in which 7 cases was found with liver metastasis, 15 with pulmonary metastasis,and 5 with brain metastasis) , there was 2 cases of CR, 13 PR,6 SD.and 2 PD. The average RR was 65. 2%(15/23) and the OCR was 91. 3%(21/23). In the ID group,9 cases of Ⅲ phase were specified as 1 case of CR,4 PR,3 SD.and 1 PD. The average RR was 55. 6% (5/9) and the DCR was 88. 9% (8/9). Of the 25 cases of the Ⅳ phase(in which 6 cases were found with liver metastasis,16 with pulmonary metastasis,and 4 with brain metastasis),there were 9 cases of PR,12 SD,4 PD, hut none of CR. The average RR was 36. 0% (9/25) and the DCR was 84. 0% (21/25). Compared with the ID group,the curative effect of Epirubicin in the MP group turned out to be more prominent(X2 = 5. 509,P = 0.027). Conclusion Administration of EPI by micro-pumping had better curative effect than by using intravenous dripping. Further study with large sample size should be carried out to validate our current observation.关键词
表阿霉素/微量泵入/静脉滴注/乳腺癌/给药方式Key words
Epirubicin/Micro-pumpng/Intravenous dripping/Breast cancer/Admistration way分类
医药卫生引用本文复制引用
杨润祥,任宏轩,聂建云,刘林,董超,高春林,庄莉,姚萍..两种不同给药方式下表阿霉素治疗乳腺癌近期疗效观察[J].肿瘤防治研究,2012,39(5):573-576,4.
