肿瘤防治研究2012，Vol.39Issue(5)：577-581,5.DOI:10.3971/j.issn.1000-8578.2012.05.021
三维适形大分割放射治疗局部中晚期非小细胞肺癌的不良反应与长期生存分析
Toxic Effect and Long-term Survival of Three Dimensional Conformal High-dose Radiotherapy for Non-small Cell Lung Cancer
沈文斌 1祝淑钗 1高红梅 2李娟 1苏景伟 1刘志坤 1李幼梅 1万钧1
作者信息
- 1. 050011石家庄,河北医科大学第四医院放疗科
- 2. 石家庄市第一医院影像科
- 折叠
摘要
Abstract
Objective To compare the long term survival and side effects of the high-dose radiotherapy with the convention radiotherapy for locally advanced non-small cell lung cancer( NSCLC) .and to analysis the prognostic factors. Methods From Jan,2000 to Jan,2004,75 patients underwent high-dose radiother-apyC HRT) and 83 patients received conventional radiotherapy(CRT) in non-small cell lung cancer were analyzed. The clinical evaluation of the patients in the recent 3 months after radiotherapy were carried out according RECIST criteria. The toxicity reaction to the patients were graded. SPSS11. 5 software was used for statistical analysis. Results The two groups had the same variable. For all patients, the overall response rate(CR + PR) was 80. 4% .and the l-,3- and 5- year survival rates were 44. 9 % , 19. 0%and
11. 7%, respectively. There were no statistics significance between HRT group and CRT group. For all patients .the 1-.3- and 5-years local control rate was 76. 8%,48. 1% and 40. 5%, respectively. There were statistics significance between HRT group and CRT group(X2 = 3. 80, P = 0. 041). The multivariate analysis showed that the maximum diameter of tumor,chemotherapy.treatment time and short-term curative effect were independent prognostic factors. Compared HRT group with CRT group, the treatment time was shorter(X2 = 3. 93, P = 0. 047) ,and the short-term curative effect was better(X2 = 9. 649,P = 0. 022). But,there were no statistics significance between the two groups in the rate of radiation injury. Conclusion The high-dose radiotherapy has a good long effective in the treatment of NSCLC. The treatment time was shorter and the side effects were not more.
关键词
非小细胞肺癌/三维适形放疗/大分割/预后/不良反应Key words
Non-small cell lung cancer/Three dimensional conformal radiotherapy/ High-dose radiothcra-py/Prognosis/Toxic effect
分类
医药卫生引用本文复制引用
沈文斌,祝淑钗,高红梅,李娟,苏景伟,刘志坤,李幼梅,万钧..三维适形大分割放射治疗局部中晚期非小细胞肺癌的不良反应与长期生存分析[J].肿瘤防治研究,2012,39(5):577-581,5.
