中山大学学报（医学科学版）2012，Vol.33Issue(3)：293-298,6.
肝细胞癌中真核延伸因子1A2的表达及意义
Expression and Its Significance of Eukaryotic Elongation Factor 1 Alpha 2 in Hepatocellular Carcinoma
摘要
Abstract
[Objective] To investigate the expression of eukaryotic elongation factor (eEF) 1A2 and its clinicopathologic characters in hepatocellular carcinoma (HCC). [Methods] Clinical pathological data of 104 HCC patients were collected. Immunohistochemical analysis for eEFlA2 was performed on tissue microarrays for these HCC and adjacent liver tissues. The expression of eEFlA2 and its clinicopathologic and prognostic significance was analyzed. [Results] Immunohistochemical analysis revealed eEFlA2 was significantly expressed (eEFlA2 ++, eEFlA2 +++) in 56.7% of HCC tissues, while it only high expressed in 13.5% adjacent liver tissues (P=0.014). Expression of eEFlA2 were associated with hepatitis B virus infection (P = 0.030) and clinical recurrence (P = 0.012). Kaplan-Meier analysis showed that patients with high expression of eEFlA2 had both longer overall survival time (P= 0.024) and recurrence-free survival time (P= 0.023) as compared with those with low expression of eEFlA2. Logistic regression analysis demonstrated eEFlA2 expression may be an independent prognostic parameter for overall survival for patients with HCC (P = 0.038). [Conclusion] EEF1A2, which is high expressed in HCC tissues, is associated with recurrence and prognosis. EEF1A2 may be a potential prognostic marker for patients with HCC.关键词
肝细胞癌/真核延伸因子1A2/预后/复发Key words
hepatocellular carcinoma/eukaryotic elongation factor 1 alpha 2/prognosis/recurrence分类
医药卫生引用本文复制引用
黄燕,易纯,李琳子,刘莉莉,陆世旬,周璇,谢国斌,云径平..肝细胞癌中真核延伸因子1A2的表达及意义[J].中山大学学报（医学科学版）,2012,33(3):293-298,6.基金项目
国家自然科学基金(30973506 （）
81172345) （）
