中山大学学报（医学科学版）2012，Vol.33Issue(3)：402-406,5.
肝癌三维适形、静态调强与容积旋转调强放射治疗的剂量学研究
Dosimetric Comparison of 3DCRT, Static IMRT, and VMAT for Hepatocellular Carcinoma
摘要
Abstract
[Objective] To compare the dose distribution between three-dimensional conformal radiotherapy (3DCRT), static intensity-modulated radiotherapy (slMRT), and volumetric modulated arc therapy (VMAT) for hepatocellular carcinoma. [Methods] The 4DCT scans of 20 patients with hepatocellular carcinoma in right lobe were selected for this comparative analysis. The 3DCRT, IMRT, and VMAT plans were prepared for each patient. Dose prescription was 50 Gy to the planning target volume (FTV) in 25 fractions. PTV dose coverage, organs at risk (OAR) doses, monitor units (MU), and treatment delivery parameters were assessed. [Results] All three plans achieved comparable Dmax. Both VMAT and IMRT showed significandy better PTV coverage, conformity, and homogeneity than 3DCRT. The mean dose to normal liver was as follows; (20.5 ± 4.5) Gy for 3DCRT, (21.1 ± 3.8) Gy for IMRT, and (20.9 ±3.9) Gy for VMAT. Comparable sparing of normal tissues including kidney, stomach, small intestine and spinal cord were achieved with all three plans. The number of MU/fraction was 405 ± 99 for 3DCRT, 392 ±1 for IMRT, and 438 ?76 for VMAT (P = 0.226). Effective treatment times for 3DCRT, IMRT and VMAT were (2.1 ±0.2) min, (4.8 ± 0.7) min, and (3.0 ± 0.2) min, respectively (P = 0.000). [Conclusion] VMAT improved delivery efficiency for equivalent dosimetric quality as IMRT. Compared with 3DCRT, IMRT and VMAT provided favorable tumor coverage, but both IMRT and VMAT were not superior to 3DCRT in terms of normal tissues protection.关键词
肝肿瘤/放射疗法/三维适形放疗/调强放射治疗/容积旋转调强Key words
liver neoplasm/radiotherapy/three-dimensional conformal radiodierapy/intensity-modulated radiotherapy/volumetric modulated arc therapy分类
医药卫生引用本文复制引用
张黎,习勉,孙文钊,梁健,黄晓延,刘孟忠..肝癌三维适形、静态调强与容积旋转调强放射治疗的剂量学研究[J].中山大学学报（医学科学版）,2012,33(3):402-406,5.基金项目
广东省科技计划项目(2009B080701036) （2009B080701036）
