中山大学学报（医学科学版）2012，Vol.33Issue(3)：412-416,5.
颈淋巴结转移对晚期喉鳞状细胞癌生存影响
Survival Impact of Cervical Metastasis in Advanced Laryngeal Squamous Cell Carcinoma
摘要
Abstract
[Objective]To explore the impact of cervical metastasis on the survival of patients with advanced laryngeal squamous cell carcinoma. [ Methods] Between January 1990 to December 2005, 312 cases of squamous cell carcinoma of the larynx hospitalized in Cancer Center, Sun Yat-sen University were reviewed retrospectively. 141 patients (45.2%) had positive clinical cervical nodal disease (cN+) and 171 patients (54.8%) had negative clinical cervical nodal disease (cNO) at initial presence. Survival differences according to presence or absence of clinical cervical nodal disease and N-stage were determined with Kaplan-Meier method and the log-rank test. [Results] The 5-year survival rates for cN+ patients and cNO were 33.7% and 60.5% (P < 0.001). The 5-year survival rates were 40.6%, 33.6%, and 0% for cNl~cN3 lesions, respectively (P < 0.001). Clinical cervical metastasis was detected in 45.2% (141/312 cases) of those individuals with advanced laryngeal squamous cell carcinoma presenting for initial clinical consultation; after therapy, those cN+ patients (141 cases) all had positive histological cervical metastasis and 30 cases (30/171, 17.5%) of those cNO individuals had positive histological cervical metastasis. Finally, 54.8% (171/312) of our patients with hiatologically positive necks manifested disease to the cervical lymph nodes. [Conclusion] The patients presence of cervical nodal disease associated with decrease survival rate. Besides, advanced N-stage significantly correlated with worse prognosis. The cervical lymphy node of advanced laryngeal squamous cell carcinoma should be treated aggressively.关键词
喉肿瘤/鳞状细胞癌/淋巴结转移Key words
larynx neoplasms/squamous cell carcinoma/cervical metastasis分类
医药卫生引用本文复制引用
张欣睿,刘学奎,李铨,刘志民,郭朱明,张诠,杨安奎,曾宗渊..颈淋巴结转移对晚期喉鳞状细胞癌生存影响[J].中山大学学报（医学科学版）,2012,33(3):412-416,5.基金项目
广东省科技计划项目(2011B031800221) （2011B031800221）
