中兽医医药杂志2012，Vol.31Issue(3)：15-17,3.
芪苓制剂多糖对环磷酰胺所致免疫损伤小鼠血清SOD和MDA的影响
Effects of polysaccharide from Qiling preparation on serum SOD and MDA in immunity damaged mice induced by cyclophosphamide
摘要
Abstract
The experiment was conducted to investigale ihe on serum SOD and MDA of immunitv damaged mice induced by cyclophosphamide. 75 Kunming male mice with 18-22 g were randomly divided into the control group, the CY group, the high dose group, the middle dose group and the low dose group. The three treated groups were given 200,400 and 600 mg·kg^-1 of polysaccharide to each mouse respectively once daily for 19 successive days. The rest groups were given the same volume of distilled water tbr 19 days. The control group were injected with saline solution, and the oflaer groups were injected with cyclophosphamide （CY） at a dose of 100 mg·kg^-1 on 20^th. The mice of each group were killed by excising eyeballs and blood smnples were collected from mice after 24 hours. Then the activity of superoxide dismutase （SOD） and the contents of nmlonaldehvde （MDA） in senam of mice were determined. The resuhs showed that the activities of SOD in polysaccharide groups were all significantly higher than that in group CY （P〈0.01）. anti the contents of MDA in the three groups were all significantly decreased （P〈0.01）. It was concluded that polysaccharide from Qiling preparation could improve antioxidant status of immunity damaged mice induced by cyclophosphamide.关键词
芪苓制剂多糖/环磷酰胺/免疫损伤小鼠/超氧化物歧化酶/丙二醛Key words
polysaccharide from Qiling preparation: cyclophosphamide: immunity damaged mice/superoxide dismutase ( SOD ) : malonaldehvde ( MDA )分类
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廖吕燕,马玉芳,李健,黄一帆..芪苓制剂多糖对环磷酰胺所致免疫损伤小鼠血清SOD和MDA的影响[J].中兽医医药杂志,2012,31(3):15-17,3.基金项目
福建农林大学校青年基金项目 （）
