中国中西医结合杂志2012，Vol.32Issue(4)：445-449,5.
137例活动期溃疡性结肠炎患者中医证型与肠黏膜象关系的研究
Study on the Correlation between Chinese Medicine Syndrome and the Intestinal Mucosal Manifestations of 137 Patients with Active Ulcerative Colitis
摘要
Abstract
Objective To observe the distribution features of Chinese medicine syndrome (CMS) in 137 patients with active ulcerative colitis (AUC), and to analyze the correlation between the intestinal mucosal manifestations and CMS. Methods Totally 137 AUC patients were syndrome typed. The intestinal mucosal manifestations were observed under endoscope, thus analyzing the correlation between the intestinal mucosal manifestations and CMS. Results In the distribution of main syndromes, the case numbers were sequenced as the damp-heat of Dachang syndrome > the yang deficiency of Pi-Shen syndrome > the Gan-depression and Pi-deficiency syndrome >the deficiency of Pi-qi syndrome >the blood stasis of the intestine meridian syndrome >the deficiency of blood and yin syndrome. The frequency of intestinal mucosal manifestations more than 50% covered mucosal damage, abnormal mucosa membrane color, congestion, edema, erosion, ulcer, pus tongue fur, and obscure or disappeared blood vessels. The edema, erosion, and ulcer occurred more in the damp-heat of Dachang syndrome, followed by the yang deficiency of Pi-Shen syndrome and the Gan-depression and Pi-deficiency syndrome (P<0.05, P<0.01). Polypi, abnormal enterokinesia, grainy occurred more in the damp-heat of Dachang syndrome and the Gan-depression and Pi-deficiency syndrome (P=0.010). Shallower plica or disappeared saccu-lations of colon occurred more in the yang deficiency of Pi-Shen syndrome and the damp-heat of Dachang syn- drome (P=0.002). The mucosa bridge occurred more in the yang deficiency of Pi-Shen syndrome and Gan-de-pression and Pi-deficiency syndrome (P=0.280). Fragility or contact bleeding occurred more in the damp-heat of Dachang syndrome, the deficiency of Pi-qi syndrome, and Gan-depression and Pi-deficiency syndrome (P = 0.045). Pale blood of the intestinal hemorrhage occurred more in the deficiency of Pi-qi syndrome while dark blood occurred more in the damp-heat of Oachang syndrome (P=0.017). Pus tongue fur occurred more in the damp-heat of Dachang syndrome, the yang deficiency of Pi-Shen syndrome, and the Gan-depression and Pi-deficiency syndrome. White pus tongue fur occurred more in the yang deficiency of Pi-Shen syndrome while yellow pus tongue fur occurred more in the damp-heat of Dachang syndrome (P<0.001). Mucus occurred more in the yang deficiency of Pi-Shen syndrome, the Gan-depression and Pi-deficiency syndrome, and the deficiency of Pi-qi syndrome (P=0.012). Narrow enteric cavity or intestinal canal fibrosis, lead pipe like manifestations occurred more in the blood stasis of the intestine meridian syndrome (P=0.001). Atrophic mucosa occurred more in the blood stasis of the intestine meridian syndrome and the deficiency of blood and yin syndrome (P < 0.001). Conclusions The intestinal mucosal manifestations of AUC showed certain laws in CMS. The microscopic differences could verify macroscopic CMS to some extent.关键词
活动期溃疡性结肠炎/中医证型/肠黏膜Key words
active ulcerative colitis/ features of Chinese medicine syndrome/ intestinal mucosa引用本文复制引用
吴健,王新月,孙慧怡,张雯,王建云,程瑞莹,刘大铭..137例活动期溃疡性结肠炎患者中医证型与肠黏膜象关系的研究[J].中国中西医结合杂志,2012,32(4):445-449,5.基金项目
国家重点基础研究发展计划“973计划”资助项目(No.2009CB522705) （No.2009CB522705）
首都医学科技发展基金项目(重点支持类)(No.F-2007-Ⅱ-02) （重点支持类）
