中国中西医结合杂志2012，Vol.32Issue(6)：766-769,4.
调免3号对封闭抗体缺乏型反复自然流产免疫调节作用
Immunoregulation Effects of Tlaomian No.3 for Recurrent Spontaneous Abortion Caused by Shortage of Blocldng Antibodies
摘要
Abstract
Objective To study the immunoregulation effects of Tiaomian No. 3 (TM3) for recurrent spontaneous abortion (RSA) caused by shortage of blocking antibodies. Methods Totally 61 patients with RSA caused by shortage of blocking antibodies were randomly assigned to the treatment group (31 cases) and the control group (30 cases) by lot method. Patients in the treatment group were treated with TM3, while those in the control group were treated with active immunotherapy using lymphocytes of their spouses. The therapeutic course for all was 3 months. Another 10 healthy females in the same age ranges were recruited as the healthy control group. The blocking antibodies (Ab1), anti-idiotypic antibodies (Ab2), T-lymphocyte cell subsets (CD4 and CD8), serum interieukin 10 (IL-10), and macrophage colony-stimulating factor (M-CSF) levels were determined before and after treatment. Results (1) After treatment the positive conversion rate of Ab, and/or Abz was 87.1% (27/31) in the treatment group and 86.7% (26/30) in the control group, showing no statistical difference (P>0.05). (2) In the two groups, CD4 decreased and CDB increased. The CD4/CDB ratio was in the normal level after treatment, showing statistical difference when compared with before treatment (P<0.05). (3) In the two groups, IL-10 and M-CSF levels were higher after treatment, showing statistical difference when compared with before treatment (P<0.05). (4) The 1-year conception rate was 58.1% (18/31) in the treatment group, significantly higher than that in the control group (46.7%, 14/30, P<0.05). Conclusions TM3 could promote the positive conversion rate of Ab,, promote the production of IL-10 and M-CSF cytokines, thus strengthening the protection for fetus by the mother and the normal maintenance for pregnancy. The 1 -year sue- cessful pregnancy rate obviously increased in the treatment group.关键词
反复自然流产/封闭抗体缺乏/抗独特型抗体缺乏/白细胞介素/中医药治疗/调免3号/巨噬细胞集落刺激因子/T淋巴细胞亚群Key words
recurrent spontaneous abortion/ the shortage of blocking antibodies/ anti-idiotype antibody/ interleukin/ Chinese medicine therapy/Tiaomian No. 3/ macrophage colony-stimulating factor/ T-lymphocyte cell subset引用本文复制引用
高汉义,陶恩学,王燕,岳启安,任春娥,闫乐法..调免3号对封闭抗体缺乏型反复自然流产免疫调节作用[J].中国中西医结合杂志,2012,32(6):766-769,4.基金项目
山东省中医药管理局立项课题(No.2007-157) （No.2007-157）
